Reviewed, UniProtKB/Swiss-Prot Q8AVD3 (KAD2_XENLA)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 2, mitochondrial
      Short name=AK 2
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 2

Gene names

Name:

ak2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Adenylate kinase 2, mitochondrial		PRO_0000365697
Regions
	Nucleotide binding	24 – 32	9	ATP By similarity
	Nucleotide binding	47 – 76	30	AMP By similarity
Sites
	Binding site	48	1	AMP By similarity
Amino acid modifications
	Disulfide bond	44 ↔ 94		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8AVD3-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5C5A7F41F52CA5D7	FASTA	241	26,527
	10 20 30 40 50 60 MAPREAAPAE RGSMMEGIRA ILLGPPGAGK GTQAPKLAEK YCVCHLATGD MLRAMVASGS 70 80 90 100 110 120 ELGKRLKATM DAGKLVSDEM VVELIEKNLD TPPCKKGFLL DGFPRTVKQA EMLDELLEKR 130 140 150 160 170 180 QEKLDSVIEF KVDDSLLVRR ICGRLIHASS GRSYHEEFNP PKEPMKDDVT GEALIRRSDD 190 200 210 220 230 240 NESTLKSRLE AYHTMTSPLV DYYQRHGIHT AVDAAQSPDV VFASILAAFS KAHCKDLVLF V

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC041509 mRNA. Translation: AAH41509.1.
RefSeq	NP_001080232.1.
UniGene	Xl.5891
3D structure databases
HSSP	HSSP built from PDB template 1AK2 based on UniProtKB P08166.
SMR	Q8AVD3. Positions 17-234.
ModBase	Search...
Genome annotation databases
GeneID	379924.
KEGG	xla:379924.
Organism-specific databases
CTD	379924.
Phylogenomic databases
HOVERGEN	Q8AVD3.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD2_XENLA

Accession

Primary (citable) accession number: Q8AVD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	March 1, 2003
Last modified:	September 1, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project