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Protein

Cysteine-rich venom protein pseudecin

Gene
N/A
Organism
Pseudechis porphyriacus (Red-bellied black snake)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Blocks olfactory (CNGA2) and retinal (CNGA1) CNG channel currents. Is really less potent that Pseudechetoxin. Does not affect neither depolarization- nor caffeine-induced contraction of smooth muscle.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Zinc1 Publication1
Metal bindingi106Zinc1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich venom protein pseudecin
Short name:
CRVP Pdc
OrganismiPseudechis porphyriacus (Red-bellied black snake)
Taxonomic identifieri8671 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaePseudechis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
PropeptideiPRO_000000628420 – 281 Publication9
ChainiPRO_000000628529 – 238Cysteine-rich venom protein pseudecinAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 153PROSITE-ProRule annotation1 Publication
Disulfide bondi92 ↔ 165PROSITE-ProRule annotation1 Publication
Disulfide bondi148 ↔ 162PROSITE-ProRule annotation1 Publication
Disulfide bondi184 ↔ 191PROSITE-ProRule annotation1 Publication
Disulfide bondi187 ↔ 196PROSITE-ProRule annotation1 Publication
Disulfide bondi200 ↔ 233PROSITE-ProRule annotation1 Publication
Disulfide bondi209 ↔ 227PROSITE-ProRule annotation1 Publication
Disulfide bondi218 ↔ 231PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 45Combined sources13
Beta strandi52 – 54Combined sources3
Helixi62 – 72Combined sources11
Turni73 – 75Combined sources3
Helixi82 – 84Combined sources3
Beta strandi85 – 87Combined sources3
Beta strandi93 – 101Combined sources9
Helixi105 – 113Combined sources9
Helixi114 – 118Combined sources5
Turni121 – 123Combined sources3
Beta strandi124 – 127Combined sources4
Helixi133 – 138Combined sources6
Beta strandi145 – 154Combined sources10
Beta strandi157 – 166Combined sources10
Beta strandi168 – 170Combined sources3
Beta strandi180 – 182Combined sources3
Turni183 – 186Combined sources4
Beta strandi190 – 192Combined sources3
Helixi209 – 216Combined sources8
Helixi221 – 226Combined sources6
Helixi228 – 232Combined sources5
Beta strandi234 – 237Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DDBX-ray1.90A/B/C/D29-238[»]
2EPFX-ray2.30A/B/C/D29-238[»]
ProteinModelPortaliQ8AVA3.
SMRiQ8AVA3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8AVA3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 164SCPAdd BLAST127
Domaini200 – 233ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004184.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8AVA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAFIVLLSL AAVLQQSSGT VDFASESSNK KNYQKEIVDK HNALRRSVKP
60 70 80 90 100
TARNMLQMKW NSHAAQNAKR WADRCTFAHS PPNTRTVGKL RCGENIFMSS
110 120 130 140 150
QPFPWSGVVQ AWYDEIKNFV YGIGAKPPGS VIGHYTQVVW YKSHLIGCAS
160 170 180 190 200
AKCSSSKYLY VCQYCPAGNI RGSIATPYKS GPPCADCPSA CVNRLCTNPC
210 220 230
NYNNDFSNCK SLAKKSKCQT EWIKKKCPAS CFCHNKII
Length:238
Mass (Da):26,452
Last modified:March 1, 2003 - v1
Checksum:i0EE4018E1274D85B
GO

Mass spectrometryi

Molecular mass is 23651.9±82.8 Da from positions 29 - 238. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072696 mRNA. Translation: AAL65292.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072696 mRNA. Translation: AAL65292.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DDBX-ray1.90A/B/C/D29-238[»]
2EPFX-ray2.30A/B/C/D29-238[»]
ProteinModelPortaliQ8AVA3.
SMRiQ8AVA3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004184.

Miscellaneous databases

EvolutionaryTraceiQ8AVA3.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRVP_PSEPO
AccessioniPrimary (citable) accession number: Q8AVA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.