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Reviewed, UniProtKB/Swiss-Prot Q8ABI8 (FABH1_BACTN)

Last modified February 9, 2010. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1
    EC=2.3.1.180
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase III protein 1
    Beta-ketoacyl-ACP synthase III 1
      Short name=KAS III 1
Gene names
Name: fabH1
Ordered Locus Names: BT_0122
OrganismBacteroides thetaiotaomicron [Complete proteome] [HAMAP]
Taxonomic identifier818 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

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Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/acpP and fabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the fabH family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3353353-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1 HAMAP MF_01815
PRO_0000110401

Regions

Region257 – 2615ACP-binding By similarity

Sites

Active site1161 By similarity
Active site2561 By similarity
Active site2861 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8ABI8-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 41321F663A1030BD

FASTA33537,220
        10         20         30         40         50         60 
MDKINAVITG VGGYVPDYVL TNDEISKMVD TTDEWIMGRI GIKERHILNE EGLGTSYMAR 

        70         80         90        100        110        120 
KAAKQLMQRT KSRPDDIDLV IVATTTSDYR FPSTASILCE RLGLKNAFAF DMQAVCSGFL 

       130        140        150        160        170        180 
YAMETGANFI RSGKYKKIII VGADKMSSVI DYTDRATCPI FGDGAAAFML EPTTEEVGIM 

       190        200        210        220        230        240 
DSVLRTDGKG LPFLHIKAGG SVCPPSYYSL DHHLHYIYQE GRTVFKYAVA NMSDSCEAII 

       250        260        270        280        290        300 
ARNHLTKEEV DWVIPHQANQ RIITAVAQRL EVPSEKVMVN IERYGNTSAG TLPLCIWDFE 

       310        320        330 
KKLKKGDNLI FTAFGAGFAW GAVYVKWGYD PKEDA

« Hide

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References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015928 Genomic DNA. Translation: AAO75229.1.
RefSeqNP_809035.1.

3D structure databases

SMRQ8ABI8. Positions 5-327.
ModBaseSearch...

Genome annotation databases

GeneID1072848.
GenomeReviewsGene locus BT_0122 in contig AE015928_GR.
KEGGbth:BT_0122.
NMPDRfig|226186.1.peg.122.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMATINIPME.
PhylomeDBQ8ABI8.

Enzyme and pathway databases

BioCycBTHE226186:BT_0122-MONOMER.
BRENDA2.3.1.180. 21018.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00747. fabH. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameFABH1_BACTN
AccessionPrimary (citable) accession number: Q8ABI8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents