Q8ABA9
HISX_BACTN
Histidinol dehydrogenase
HDH
1.1.1.23
hisD
BT_0201
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
Bacteria
Bacteroidota
Bacteroidia
Bacteroidales
Bacteroidaceae
Bacteroides
A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH
Zn(2+)
Binds 1 zinc ion per subunit.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Belongs to the histidinol dehydrogenase family.
Amino-acid biosynthesis
Histidine biosynthesis
Metal-binding
NAD
Oxidoreductase
Reference proteome
Zinc
NAD(+)
NAD(+)
NAD(+)
substrate
substrate
Zn(2+)
substrate
Zn(2+)
substrate
substrate
Zn(2+)
substrate
substrate
Zn(2+)
MMKLIKYPSKEQWAELLKRPALNTESLFDTVRTIINKVRAEGDKAVLEYEAAFDKVTLSALTVTSEEIQKAEGLISDELKSAITLAKRNIETFHSSQRFVGKKVETMEGVTCWQKAVGIEKVGLYIPGGTAPLFSTVLMLAVPAKIAGCREIVLCTPPDKNGNIHPAILFAAQLAGVSKIFKAGGVQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQLVSLRDVAIDMPAGPSEVEVLADASANPVFVAADLLSQAEHGVDSQAMLITTSEKLQAEVMEEVNRQLAKLPRREIAAKSLENSKLILVKDMDEALELTNAYAPEHLIVETENYLEVAERVINAGSVFLGSLTPESAGDYASGTNHTLPTNGYAKAYSGVSLDSFIRKITFQEILPQGMKVIGPAIEEMAANELLDAHKNAVTVRLNTLK
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