Q8AAW1 (ARAA_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	BT_0351

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	L-arabinose isomerase HAMAP MF_00519		PRO_0000312601
Sites
	Metal binding	313	1	Manganese By similarity
	Metal binding	340	1	Manganese By similarity
	Metal binding	357	1	Manganese By similarity
	Metal binding	456	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8AAW1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: DE04E4669834332C	FASTA	509	57,174
	10 20 30 40 50 60 MNNVFDQYEV WFVTGAQLLY GGDAVIAVDA HSNEMVNGLN ESGKLPVKVV YKGTANSSKE 70 80 90 100 110 120 VEAVFKAANN DDKCVGVITW MHTFSPAKMW IHGLQQLKKP LLHLHTQFNK EIPWDTMDMD 130 140 150 160 170 180 FMNLNQSAHG DREFGHICTR MRIRRKVVVG YWKEEETLHK IAVWMRVCAG WADSQDMLII 190 200 210 220 230 240 RFGDQMNNVA VTDGDKVEAE QRMGYHVDYC PASELMEYHK DIKNADVDAL VATYFNDYDH 250 260 270 280 290 300 DASLEDKSTE AYQKVWNAAK AELALRAILK AKGAKGFTTN FDDLGQTDGS YFDQIPGLAS 310 320 330 340 350 360 QRLMAEGYGF GAEGDWKSAA LYRTVWVMNQ GLPKGCSFLE DYTLNFDGAN SSILQSHMLE 370 380 390 400 410 420 ICPLIAANKP RLEVHFLGIG IRKSQTARLV FTSKTGTGCT ATVVDMGNRF RLIVNDVECI 430 440 450 460 470 480 EPKPLPKLPV ASALWIPMPN LEVGAGAWIL AGGTHHSCFS YDLTAEYWED YAEIAGIEMV 490 500 HINKDTTISC FKKELRMNEV YYMLNKALC

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO75458.1.
RefSeq	NP_809264.1. NC_004663.1.
3D structure databases
HSSP	HSSP built from PDB template 2AJT based on UniProtKB P08202.
ProteinModelPortal	Q8AAW1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1072405.
GenomeReviews	Gene locus BT_0351 in contig AE015928_GR.
KEGG	bth:BT_0351.
NMPDR	fig|226186.1.peg.351.
PATRIC	21055445. VBIBacThe70966_0350.
Phylogenomic databases
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	Q8AAW1.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_0351-MONOMER.
BRENDA	5.3.1.4. 773.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_BACTN

Accession

Primary (citable) accession number: Q8AAW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program