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Q8AAW1 (ARAA_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-arabinose isomerase

EC=5.3.1.4
Gene names
Name:araA
Ordered Locus Names:BT_0351
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519

Catalytic activity

L-arabinose = L-ribulose. HAMAP MF_00519

Cofactor

Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519

Pathway

Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519

Sequence similarities

Belongs to the arabinose isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509L-arabinose isomerase HAMAP MF_00519
PRO_0000312601

Sites

Metal binding3131Manganese By similarity
Metal binding3401Manganese By similarity
Metal binding3571Manganese By similarity
Metal binding4561Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8AAW1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: DE04E4669834332C

FASTA50957,174
        10         20         30         40         50         60 
MNNVFDQYEV WFVTGAQLLY GGDAVIAVDA HSNEMVNGLN ESGKLPVKVV YKGTANSSKE 

        70         80         90        100        110        120 
VEAVFKAANN DDKCVGVITW MHTFSPAKMW IHGLQQLKKP LLHLHTQFNK EIPWDTMDMD 

       130        140        150        160        170        180 
FMNLNQSAHG DREFGHICTR MRIRRKVVVG YWKEEETLHK IAVWMRVCAG WADSQDMLII 

       190        200        210        220        230        240 
RFGDQMNNVA VTDGDKVEAE QRMGYHVDYC PASELMEYHK DIKNADVDAL VATYFNDYDH 

       250        260        270        280        290        300 
DASLEDKSTE AYQKVWNAAK AELALRAILK AKGAKGFTTN FDDLGQTDGS YFDQIPGLAS 

       310        320        330        340        350        360 
QRLMAEGYGF GAEGDWKSAA LYRTVWVMNQ GLPKGCSFLE DYTLNFDGAN SSILQSHMLE 

       370        380        390        400        410        420 
ICPLIAANKP RLEVHFLGIG IRKSQTARLV FTSKTGTGCT ATVVDMGNRF RLIVNDVECI 

       430        440        450        460        470        480 
EPKPLPKLPV ASALWIPMPN LEVGAGAWIL AGGTHHSCFS YDLTAEYWED YAEIAGIEMV 

       490        500 
HINKDTTISC FKKELRMNEV YYMLNKALC 

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO75458.1.
RefSeqNP_809264.1. NC_004663.1.

3D structure databases

HSSPHSSP built from PDB template 2AJT based on UniProtKB P08202.
ProteinModelPortalQ8AAW1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1072405.
GenomeReviewsGene locus BT_0351 in contig AE015928_GR.
KEGGbth:BT_0351.
NMPDRfig|226186.1.peg.351.
PATRIC21055445. VBIBacThe70966_0350.

Phylogenomic databases

HOGENOMHBG297198.
OMAEVCPTIA.
PhylomeDBQ8AAW1.
ProtClustDBPRK02929.

Enzyme and pathway databases

BioCycBTHE226186:BT_0351-MONOMER.
BRENDA5.3.1.4. 773.

Family and domain databases

HAMAPMF_00519. Arabinose_Isome.
[Tree]
InterProIPR024664. Ara_Isoase_C.
IPR004216. Fuc/Ara_isomerase_C.
IPR009015. Fucose_isomerase_N/cen.
IPR003762. Lara_isomerase.
[Graphical view]
KOK01804.
PfamPF11762. Arabinose_Iso_C. 1 hit.
PF02610. Arabinose_Isome. 1 hit.
[Graphical view]
PIRSFPIRSF001478. L-ara_isomerase. 1 hit.
ProDomPD018364. Lara_isomerase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50443. Fuc_isomerase_C. 1 hit.
SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARAA_BACTN
AccessionPrimary (citable) accession number: Q8AAW1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families