ID   Q8AAK9_BACTN            Unreviewed;       544 AA.
AC   Q8AAK9;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   SubName: Full=Sialidase (Neuraminidase) {ECO:0000313|EMBL:AAO75562.1};
GN   OrderedLocusNames=BT_0455 {ECO:0000313|EMBL:AAO75562.1};
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO75562.1, ECO:0000313|Proteomes:UP000001414};
RN   [1] {ECO:0000313|EMBL:AAO75562.1, ECO:0000313|Proteomes:UP000001414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
RN   [2] {ECO:0000313|EMBL:AAO75562.1, ECO:0000313|Proteomes:UP000001414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX   PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA   Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA   Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA   Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA   Hettich R.L., Gordon J.I.;
RT   "Characterizing a model human gut microbiota composed of members of its two
RT   dominant bacterial phyla.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
RN   [3] {ECO:0007829|PDB:4BBW}
RP   X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
RX   PubMed=23665536; DOI=10.1016/J.BBAPAP.2013.04.028;
RA   Park K.H., Kim M.G., Ahn H.J., Lee D.H., Kim J.H., Kim Y.W., Woo E.J.;
RT   "Structural and biochemical characterization of the broad substrate
RT   specificity of Bacteroides thetaiotaomicron commensal sialidase.";
RL   Biochim. Biophys. Acta 1834:1510-1519(2013).
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DR   EMBL; AE015928; AAO75562.1; -; Genomic_DNA.
DR   RefSeq; NP_809368.1; NC_004663.1.
DR   RefSeq; WP_008766031.1; NC_004663.1.
DR   PDB; 4BBW; X-ray; 2.30 A; A=1-544.
DR   PDBsum; 4BBW; -.
DR   AlphaFoldDB; Q8AAK9; -.
DR   SMR; Q8AAK9; -.
DR   STRING; 226186.BT_0455; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 226186-BT_0455; -.
DR   EnsemblBacteria; AAO75562; AAO75562; BT_0455.
DR   GeneID; 60926415; -.
DR   KEGG; bth:BT_0455; -.
DR   PATRIC; fig|226186.12.peg.455; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_10; -.
DR   InParanoid; Q8AAK9; -.
DR   OrthoDB; 7294637at2; -.
DR   BRENDA; 3.2.1.18; 709.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IBA:GO_Central.
DR   GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4BBW};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..544
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004303560"
FT   DOMAIN          24..172
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          205..484
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   544 AA;  60798 MW;  8D28598913230321 CRC64;
     MKRNHYLFTL ILLLGCSIFV KASDTVFVHQ TQIPILIERQ DNVLFYFRLD AKESRMMDEI
     VLDFGKSVNL SDVQAVKLYY GGTEALQDKG KKRFAPVDYI SSHRPGNTLA AIPSYSIKCA
     EALQPSAKVV LKSHYKLFPG INFFWISLQM KPETSLFTKI SSELQSVKID GKEAICEERS
     PKDIIHRMAV GVRHAGDDGS ASFRIPGLVT SNKGTLLGVY DVRYNSSVDL QEYVDVGLSR
     STDGGKTWEK MRLPLSFGEY DGLPAAQNGV GDPSILVDTQ TNTIWVVAAW THGMGNQRAW
     WSSHPGMDLY QTAQLVMAKS TDDGKTWSKP INITEQVKDP SWYFLLQGPG RGITMSDGTL
     VFPTQFIDST RVPNAGIMYS KDRGKTWKMH NMARTNTTEA QVVETEPGVL MLNMRDNRGG
     SRAVAITKDL GKTWTEHPSS RKALQEPVCM ASLIHVEAED NVLDKDILLF SNPNTTRGRN
     HITIKASLDD GLTWLPEHQL MLDEGEGWGY SCLTMIDRET IGILYESSAA HMTFQAVKLK
     DLIR
//