Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Sialidase (Neuraminidase)

Gene

BT_0455

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-457-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Sialidase (Neuraminidase)Imported
Gene namesi
Ordered Locus Names:BT_0455Imported
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_0455.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BBWX-ray2.30A1-544[»]
ProteinModelPortaliQ8AAK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiQ8AAK9.
KOiK01186.
OMAiTWSAPIN.
OrthoDBiEOG67DPK3.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF14873. BNR_assoc_N. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8AAK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRNHYLFTL ILLLGCSIFV KASDTVFVHQ TQIPILIERQ DNVLFYFRLD
60 70 80 90 100
AKESRMMDEI VLDFGKSVNL SDVQAVKLYY GGTEALQDKG KKRFAPVDYI
110 120 130 140 150
SSHRPGNTLA AIPSYSIKCA EALQPSAKVV LKSHYKLFPG INFFWISLQM
160 170 180 190 200
KPETSLFTKI SSELQSVKID GKEAICEERS PKDIIHRMAV GVRHAGDDGS
210 220 230 240 250
ASFRIPGLVT SNKGTLLGVY DVRYNSSVDL QEYVDVGLSR STDGGKTWEK
260 270 280 290 300
MRLPLSFGEY DGLPAAQNGV GDPSILVDTQ TNTIWVVAAW THGMGNQRAW
310 320 330 340 350
WSSHPGMDLY QTAQLVMAKS TDDGKTWSKP INITEQVKDP SWYFLLQGPG
360 370 380 390 400
RGITMSDGTL VFPTQFIDST RVPNAGIMYS KDRGKTWKMH NMARTNTTEA
410 420 430 440 450
QVVETEPGVL MLNMRDNRGG SRAVAITKDL GKTWTEHPSS RKALQEPVCM
460 470 480 490 500
ASLIHVEAED NVLDKDILLF SNPNTTRGRN HITIKASLDD GLTWLPEHQL
510 520 530 540
MLDEGEGWGY SCLTMIDRET IGILYESSAA HMTFQAVKLK DLIR
Length:544
Mass (Da):60,798
Last modified:June 1, 2003 - v1
Checksum:i8D28598913230321
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75562.1.
RefSeqiNP_809368.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO75562; AAO75562; BT_0455.
GeneIDi1071627.
KEGGibth:BT_0455.
PATRICi21055657. VBIBacThe70966_0455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75562.1.
RefSeqiNP_809368.1. NC_004663.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BBWX-ray2.30A1-544[»]
ProteinModelPortaliQ8AAK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_0455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO75562; AAO75562; BT_0455.
GeneIDi1071627.
KEGGibth:BT_0455.
PATRICi21055657. VBIBacThe70966_0455.

Phylogenomic databases

InParanoidiQ8AAK9.
KOiK01186.
OMAiTWSAPIN.
OrthoDBiEOG67DPK3.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-457-MONOMER.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF14873. BNR_assoc_N. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VPI-5482Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482Imported.
  3. "Structural and biochemical characterization of the broad substrate specificity of Bacteroides thetaiotaomicron commensal sialidase."
    Park K.H., Kim M.G., Ahn H.J., Lee D.H., Kim J.H., Kim Y.W., Woo E.J.
    Biochim. Biophys. Acta 1834:1510-1519(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

Entry informationi

Entry nameiQ8AAK9_BACTN
AccessioniPrimary (citable) accession number: Q8AAK9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.