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Q8AAK9

- Q8AAK9_BACTN

UniProt

Q8AAK9 - Q8AAK9_BACTN

Protein
Submitted name:

Sialidase (Neuraminidase)

Gene

BT_0455

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. exo-alpha-sialidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Enzyme and pathway databases

    BioCyciBTHE226186:GJXV-457-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Sialidase (Neuraminidase)Imported
    Gene namesi
    Ordered Locus Names:BT_0455Imported
    OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
    Taxonomic identifieri226186 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000001414: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi226186.BT_0455.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BBWX-ray2.30A1-544[»]
    ProteinModelPortaliQ8AAK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK01186.
    OMAiINITEQV.
    OrthoDBiEOG67DPK3.

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR026856. Sialidase_fam.
    IPR029456. Sialidase_N.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PfamiPF14873. BNR_assoc_N. 1 hit.
    [Graphical view]
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8AAK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRNHYLFTL ILLLGCSIFV KASDTVFVHQ TQIPILIERQ DNVLFYFRLD    50
    AKESRMMDEI VLDFGKSVNL SDVQAVKLYY GGTEALQDKG KKRFAPVDYI 100
    SSHRPGNTLA AIPSYSIKCA EALQPSAKVV LKSHYKLFPG INFFWISLQM 150
    KPETSLFTKI SSELQSVKID GKEAICEERS PKDIIHRMAV GVRHAGDDGS 200
    ASFRIPGLVT SNKGTLLGVY DVRYNSSVDL QEYVDVGLSR STDGGKTWEK 250
    MRLPLSFGEY DGLPAAQNGV GDPSILVDTQ TNTIWVVAAW THGMGNQRAW 300
    WSSHPGMDLY QTAQLVMAKS TDDGKTWSKP INITEQVKDP SWYFLLQGPG 350
    RGITMSDGTL VFPTQFIDST RVPNAGIMYS KDRGKTWKMH NMARTNTTEA 400
    QVVETEPGVL MLNMRDNRGG SRAVAITKDL GKTWTEHPSS RKALQEPVCM 450
    ASLIHVEAED NVLDKDILLF SNPNTTRGRN HITIKASLDD GLTWLPEHQL 500
    MLDEGEGWGY SCLTMIDRET IGILYESSAA HMTFQAVKLK DLIR 544
    Length:544
    Mass (Da):60,798
    Last modified:June 1, 2003 - v1
    Checksum:i8D28598913230321
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO75562.1.
    RefSeqiNP_809368.1. NC_004663.1.

    Genome annotation databases

    EnsemblBacteriaiAAO75562; AAO75562; BT_0455.
    GeneIDi1071627.
    KEGGibth:BT_0455.
    PATRICi21055657. VBIBacThe70966_0455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO75562.1 .
    RefSeqi NP_809368.1. NC_004663.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BBW X-ray 2.30 A 1-544 [» ]
    ProteinModelPortali Q8AAK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226186.BT_0455.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO75562 ; AAO75562 ; BT_0455 .
    GeneIDi 1071627.
    KEGGi bth:BT_0455.
    PATRICi 21055657. VBIBacThe70966_0455.

    Phylogenomic databases

    KOi K01186.
    OMAi INITEQV.
    OrthoDBi EOG67DPK3.

    Enzyme and pathway databases

    BioCyci BTHE226186:GJXV-457-MONOMER.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR026856. Sialidase_fam.
    IPR029456. Sialidase_N.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    Pfami PF14873. BNR_assoc_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
      Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
      Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VPI-5482Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482Imported.
    3. "Structural and biochemical characterization of the broad substrate specificity of Bacteroides thetaiotaomicron commensal sialidase."
      Park K.H., Kim M.G., Ahn H.J., Lee D.H., Kim J.H., Kim Y.W., Woo E.J.
      Biochim. Biophys. Acta 1834:1510-1519(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

    Entry informationi

    Entry nameiQ8AAK9_BACTN
    AccessioniPrimary (citable) accession number: Q8AAK9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3