Q8AAD6 (TRPC_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BT_0529

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154214

Sequences

	Sequence		Length	Mass (Da)
	Q8AAD6 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 37313A7ACB605E67	FASTA	260	28,828
	10 20 30 40 50 60 MKDILSEIIA NKRFEVDLQK QAISIEQLQE GINEVPASRS MKRALASSDS GIIAEFKRRS 70 80 90 100 110 120 PSKGWIKQEA RPEEIVPSYL AAGASALSIL TDEKFFGGSL KDIRTARPLV DVPIIRKDFI 130 140 150 160 170 180 IDEYQLYQAK IVGADAVLLI AAALKQEKCQ ELAEQAHELG LEVLLEIHSA EELPYINSKI 190 200 210 220 230 240 DMIGINNRNL GTFFTDVENS FRLAGQLPQD AVLVSESGIS DPEVVKRLRT AGFRGFLIGE 250 260 TFMKTPQPGE TLQNFLKAIQ

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO75636.1.
RefSeq	NP_809442.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8AAD6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1071979.
GenomeReviews	Gene locus BT_0529 in contig AE015928_GR.
KEGG	bth:BT_0529.
NMPDR	fig|226186.1.peg.529.
PATRIC	21055805. VBIBacThe70966_0529.
Phylogenomic databases
HOGENOM	HBG540956.
OMA	LEYAVPH.
PhylomeDB	Q8AAD6.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_0529-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACTN

Accession

Primary (citable) accession number: Q8AAD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program