Q8AAB7 (DAPF_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7

Gene names

Name:	dapF
Ordered Locus Names:	BT_0548

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197
Subcellular location	Cytoplasm By similarity HAMAP MF_00197.
Sequence similarities	Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	diaminopimelate epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Diaminopimelate epimerase HAMAP MF_00197		PRO_0000149821
Sites
	Active site	75	1	By similarity
	Active site	210	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8AAB7 [UniParc]. Last modified June 20, 2003. Version 1. Checksum: 7BE62A3C36B3A3FF	FASTA	267	28,970
	10 20 30 40 50 60 MTTKIKFTKM HGAGNDYIYV DTTRYPIAAP EKKAIEWSKF HTGIGSDGLI LIGSSDKADF 70 80 90 100 110 120 SMRIFNADGS EAMMCGNGSR CVGKYVYEYG LTAKKEITLD TRSGIKVLKL HVEGGKVTAV 130 140 150 160 170 180 TVDMGSPLET EAVDFGDQFP FQSTRVSMGN PHLVTFVEDI TQINLPEIGP QLENYHLFPD 190 200 210 220 230 240 RTNVEFAQIV GKDTIRMRVW ERGSGITQAC GTGACATAVA AVLHGLAGRK CDIIMDGGTV 250 260 TIEWEEATGH ILMTGPATKV FDGEMEG

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO75655.1.
RefSeq	NP_809461.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8AAB7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1072044.
GenomeReviews	Gene locus BT_0548 in contig AE015928_GR.
KEGG	bth:BT_0548.
NMPDR	fig|226186.1.peg.548.
PATRIC	21055843. VBIBacThe70966_0548.
Phylogenomic databases
HOGENOM	HBG399442.
OMA	DIGNPHL.
PhylomeDB	Q8AAB7.
ProtClustDB	PRK00450.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_0548-MONOMER.
Family and domain databases
HAMAP	MF_00197. DAP_epimerase. [Tree]
InterPro	IPR018510. DAP_epimerase_AS. IPR001653. DAP_epimerase_DapF. [Graphical view]
KO	K01778.
Pfam	PF01678. DAP_epimerase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00652. DapF. 1 hit.
PROSITE	PS01326. DAP_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPF_BACTN

Accession

Primary (citable) accession number: Q8AAB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	June 20, 2003
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program