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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei609 – 6091For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-556-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BT_0554
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 614613Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135301Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_0554.

Structurei

3D structure databases

ProteinModelPortaliQ8AAB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 221220Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini291 – 430140SIS 1UniRule annotationAdd
BLAST
Domaini463 – 604142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
InParanoidiQ8AAB1.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8AAB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGK RKAYPILIKG LKRLEYRGYD SAGVALISDN QQLNVYKTKG
60 70 80 90 100
KVSELENFVT QKDISGTVGI AHTRWATHGE PCSVNAHPHY SSSEKLALIH
110 120 130 140 150
NGIIENYAVL KEKLQAKGYV FKSSTDTEVL VQLIEYMKVT NRVDLLTAVQ
160 170 180 190 200
LALNEVIGAY AIAILDKEHP EEIIAARKSS PLVVGIGEDE FFLASDATPI
210 220 230 240 250
VEYTDKVVYL EDGEIAVINR GKELKVVDLS NVEMTPEVKK VELKLGQLEK
260 270 280 290 300
GGYPHFMLKE IFEQPDCIHD CMRGRINVEA NNVVLSAVID YKEKLLNAKR
310 320 330 340 350
FIIVACGTSW HAGLIGKHLI ESFCRIPVEV EYASEFRYRD PVIDEHDVVI
360 370 380 390 400
AISQSGETAD TLAAVELAKS RGAFIYGICN AIGSSIPRAT HTGSYIHVGP
410 420 430 440 450
EIGVASTKAF TGQVTVLTML ALTLAREKGT IDETQYLNIV RELNSIPGKM
460 470 480 490 500
KEVLKLNDKL AELSKTFTYA HNFIYLGRGY SYPVALEGAL KLKEISYIHA
510 520 530 540 550
EGYPAAEMKH GPIALIDAEM PVVVIATQNG LYEKVLSNIQ EIKARKGKVI
560 570 580 590 600
AFVTKGDTVI SKIADCSIEL PETIECLDPL ITTVPLQLLA YHIAVCKGMD
610
VDQPRNLAKS VTVE
Length:614
Mass (Da):67,594
Last modified:January 23, 2007 - v2
Checksum:i310FBC0FA736C4BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75661.1.
RefSeqiNP_809467.1. NC_004663.1.
WP_008765067.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO75661; AAO75661; BT_0554.
GeneIDi1072041.
KEGGibth:BT_0554.
PATRICi21055855. VBIBacThe70966_0554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75661.1.
RefSeqiNP_809467.1. NC_004663.1.
WP_008765067.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8AAB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_0554.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO75661; AAO75661; BT_0554.
GeneIDi1072041.
KEGGibth:BT_0554.
PATRICi21055855. VBIBacThe70966_0554.

Phylogenomic databases

eggNOGiCOG0449.
InParanoidiQ8AAB1.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-556-MONOMER.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiGLMS_BACTN
AccessioniPrimary (citable) accession number: Q8AAB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.