SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8AAB1

- GLMS_BACTN

UniProt

Q8AAB1 - GLMS_BACTN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, BT_0554
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei609 – 6091For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-556-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:BT_0554
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 614613Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135301Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_0554.

Structurei

3D structure databases

ProteinModelPortaliQ8AAB1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 221220Glutamine amidotransferase type-2
Add
BLAST
Domaini291 – 430140SIS 1
Add
BLAST
Domaini463 – 604142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiRIIICAC.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8AAB1-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYIGK RKAYPILIKG LKRLEYRGYD SAGVALISDN QQLNVYKTKG    50
KVSELENFVT QKDISGTVGI AHTRWATHGE PCSVNAHPHY SSSEKLALIH 100
NGIIENYAVL KEKLQAKGYV FKSSTDTEVL VQLIEYMKVT NRVDLLTAVQ 150
LALNEVIGAY AIAILDKEHP EEIIAARKSS PLVVGIGEDE FFLASDATPI 200
VEYTDKVVYL EDGEIAVINR GKELKVVDLS NVEMTPEVKK VELKLGQLEK 250
GGYPHFMLKE IFEQPDCIHD CMRGRINVEA NNVVLSAVID YKEKLLNAKR 300
FIIVACGTSW HAGLIGKHLI ESFCRIPVEV EYASEFRYRD PVIDEHDVVI 350
AISQSGETAD TLAAVELAKS RGAFIYGICN AIGSSIPRAT HTGSYIHVGP 400
EIGVASTKAF TGQVTVLTML ALTLAREKGT IDETQYLNIV RELNSIPGKM 450
KEVLKLNDKL AELSKTFTYA HNFIYLGRGY SYPVALEGAL KLKEISYIHA 500
EGYPAAEMKH GPIALIDAEM PVVVIATQNG LYEKVLSNIQ EIKARKGKVI 550
AFVTKGDTVI SKIADCSIEL PETIECLDPL ITTVPLQLLA YHIAVCKGMD 600
VDQPRNLAKS VTVE 614
Length:614
Mass (Da):67,594
Last modified:January 23, 2007 - v2
Checksum:i310FBC0FA736C4BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO75661.1.
RefSeqiNP_809467.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO75661; AAO75661; BT_0554.
GeneIDi1072041.
KEGGibth:BT_0554.
PATRICi21055855. VBIBacThe70966_0554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO75661.1 .
RefSeqi NP_809467.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8AAB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_0554.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO75661 ; AAO75661 ; BT_0554 .
GeneIDi 1072041.
KEGGi bth:BT_0554.
PATRICi 21055855. VBIBacThe70966_0554.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi RIIICAC.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BTHE226186:GJXV-556-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiGLMS_BACTN
AccessioniPrimary (citable) accession number: Q8AAB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi