Reviewed,
UniProtKB/Swiss-Prot Q8A9S8 (FTHS_BACTN)
Last modified
November 3, 2009.
Version 46.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Formate--tetrahydrofolate ligase EC=6.3.4.3 Alternative name(s): Formyltetrahydrofolate synthetase Short name=FHS Short name=FTHFS | ||||
| Gene names |
| ||||
| Organism | Bacteroides thetaiotaomicron [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 818 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides |
Protein attributes
| Sequence length | 555 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 |
| Pathway | One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 |
| Sequence similarities | Belongs to the formate--tetrahydrofolate ligase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 555 | 555 | Formate--tetrahydrofolate ligase HAMAP MF_01543 | PRO_0000199335 | |||||
Regions | |||||||||
| Nucleotide binding | 64 – 71 | 8 | ATP By similarity | ||||||
Sequences
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References
| [1] | "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482. |
Cross-references
Sequence databases | |
|---|---|
| AE015928 Genomic DNA. Translation: AAO75844.1. | |
| RefSeq | NP_809650.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FPM based on UniProtKB P21164. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1073612. |
| GenomeReviews | Gene locus BT_0737 in contig AE015928_GR. |
| KEGG | bth:BT_0737. |
| NMPDR | fig|226186.1.peg.737. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8A9S8. |
| OMA | GMKGGAT. |
Enzyme and pathway databases | |
| BioCyc | BTHE226186:BT_0737-MON. |
| BRENDA | 6.3.4.3. 21018. |
Family and domain databases | |
| HAMAP | MF_01543. [Tree] |
| InterPro | IPR000559. For_THF_ligase. [Graphical view] |
| Pfam | PF01268. FTHFS. 1 hit. [Graphical view] |
| PROSITE | PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FTHS_BACTN | ||||||||
| Accession | Primary (citable) accession number: Q8A9S8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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