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Q8A9S8

- FTHS_BACTN

UniProt

Q8A9S8 - FTHS_BACTN

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBTHE226186:GJXV-745-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:BT_0737
    OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
    Taxonomic identifieri226186 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000001414: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199335Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226186.BT_0737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8A9S8.
    SMRiQ8A9S8. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiDPKKINA.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8A9S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSDIEIARS VELKKIKQVA ESIGIPREEV ENYGRYIAKI PEQLIDEEKV    50
    KKSNLVLVTA ITATKAGIGK TTVSIGLALG LNKIGKKAIV ALREPSLGPC 100
    FGMKGGAAGG GYAQVLPMEK INLHFTGDFH AITSAHNMIS ALLDNYLYQN 150
    QAKGFGLKEI LWRRVLDVND RSLRSIVVGL GPKSNGITQE SGFDITPASE 200
    IMAILCLSKD VEDLRRRIEN ILLGFTYDDQ PFTVKDLGVA GAITVLLKDA 250
    IHPNLVQTTE GTAAFVHGGP FANIAHGCNS ILATKLAMSF GDYVITEAGF 300
    GADLGAEKFY NIKCRKSGLQ PKLTVIVATA QGLKMHGGVS LDRIKEPNME 350
    GLKEGLRNLD KHIRNLRSFG QTVVVAFNKF ATDTDEEMEM LREHCEQLGV 400
    GYAINNAFSD GGDGAVDMAR LVVDTIENNP SEPLRYTYKE EDSIQQKIEK 450
    VATNLYGASV ITYSSIARNR IKLIEKMGIT HYPVCIAKTQ YSFSADPKIY 500
    GAVNNFEFHI KDIVINNGAE MIVAIAGEIL RMPGLPKEPQ ALHIDIVDGE 550
    IEGLS 555
    Length:555
    Mass (Da):60,482
    Last modified:June 1, 2003 - v1
    Checksum:i2E9B6E45357D0F8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO75844.1.
    RefSeqiNP_809650.1. NC_004663.1.

    Genome annotation databases

    EnsemblBacteriaiAAO75844; AAO75844; BT_0737.
    GeneIDi1073612.
    KEGGibth:BT_0737.
    PATRICi21056263. VBIBacThe70966_0752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO75844.1 .
    RefSeqi NP_809650.1. NC_004663.1.

    3D structure databases

    ProteinModelPortali Q8A9S8.
    SMRi Q8A9S8. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226186.BT_0737.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO75844 ; AAO75844 ; BT_0737 .
    GeneIDi 1073612.
    KEGGi bth:BT_0737.
    PATRICi 21056263. VBIBacThe70966_0752.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi DPKKINA.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci BTHE226186:GJXV-745-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
      Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
      Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

    Entry informationi

    Entry nameiFTHS_BACTN
    AccessioniPrimary (citable) accession number: Q8A9S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3