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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway:itetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-745-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BT_0737
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199335Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_0737.

Structurei

3D structure databases

ProteinModelPortaliQ8A9S8.
SMRiQ8A9S8. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
InParanoidiQ8A9S8.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8A9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEIARS VELKKIKQVA ESIGIPREEV ENYGRYIAKI PEQLIDEEKV
60 70 80 90 100
KKSNLVLVTA ITATKAGIGK TTVSIGLALG LNKIGKKAIV ALREPSLGPC
110 120 130 140 150
FGMKGGAAGG GYAQVLPMEK INLHFTGDFH AITSAHNMIS ALLDNYLYQN
160 170 180 190 200
QAKGFGLKEI LWRRVLDVND RSLRSIVVGL GPKSNGITQE SGFDITPASE
210 220 230 240 250
IMAILCLSKD VEDLRRRIEN ILLGFTYDDQ PFTVKDLGVA GAITVLLKDA
260 270 280 290 300
IHPNLVQTTE GTAAFVHGGP FANIAHGCNS ILATKLAMSF GDYVITEAGF
310 320 330 340 350
GADLGAEKFY NIKCRKSGLQ PKLTVIVATA QGLKMHGGVS LDRIKEPNME
360 370 380 390 400
GLKEGLRNLD KHIRNLRSFG QTVVVAFNKF ATDTDEEMEM LREHCEQLGV
410 420 430 440 450
GYAINNAFSD GGDGAVDMAR LVVDTIENNP SEPLRYTYKE EDSIQQKIEK
460 470 480 490 500
VATNLYGASV ITYSSIARNR IKLIEKMGIT HYPVCIAKTQ YSFSADPKIY
510 520 530 540 550
GAVNNFEFHI KDIVINNGAE MIVAIAGEIL RMPGLPKEPQ ALHIDIVDGE

IEGLS
Length:555
Mass (Da):60,482
Last modified:June 1, 2003 - v1
Checksum:i2E9B6E45357D0F8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75844.1.
RefSeqiNP_809650.1. NC_004663.1.
WP_011107423.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO75844; AAO75844; BT_0737.
GeneIDi1073612.
KEGGibth:BT_0737.
PATRICi21056263. VBIBacThe70966_0752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75844.1.
RefSeqiNP_809650.1. NC_004663.1.
WP_011107423.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8A9S8.
SMRiQ8A9S8. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_0737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO75844; AAO75844; BT_0737.
GeneIDi1073612.
KEGGibth:BT_0737.
PATRICi21056263. VBIBacThe70966_0752.

Phylogenomic databases

eggNOGiCOG2759.
InParanoidiQ8A9S8.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciBTHE226186:GJXV-745-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiFTHS_BACTN
AccessioniPrimary (citable) accession number: Q8A9S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.