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Q8A9S8

- FTHS_BACTN

UniProt

Q8A9S8 - FTHS_BACTN

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, BT_0737
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-745-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BT_0737
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199335Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_0737.

Structurei

3D structure databases

ProteinModelPortaliQ8A9S8.
SMRiQ8A9S8. Positions 4-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiDPKKINA.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8A9S8-1 [UniParc]FASTAAdd to Basket

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MKSDIEIARS VELKKIKQVA ESIGIPREEV ENYGRYIAKI PEQLIDEEKV    50
KKSNLVLVTA ITATKAGIGK TTVSIGLALG LNKIGKKAIV ALREPSLGPC 100
FGMKGGAAGG GYAQVLPMEK INLHFTGDFH AITSAHNMIS ALLDNYLYQN 150
QAKGFGLKEI LWRRVLDVND RSLRSIVVGL GPKSNGITQE SGFDITPASE 200
IMAILCLSKD VEDLRRRIEN ILLGFTYDDQ PFTVKDLGVA GAITVLLKDA 250
IHPNLVQTTE GTAAFVHGGP FANIAHGCNS ILATKLAMSF GDYVITEAGF 300
GADLGAEKFY NIKCRKSGLQ PKLTVIVATA QGLKMHGGVS LDRIKEPNME 350
GLKEGLRNLD KHIRNLRSFG QTVVVAFNKF ATDTDEEMEM LREHCEQLGV 400
GYAINNAFSD GGDGAVDMAR LVVDTIENNP SEPLRYTYKE EDSIQQKIEK 450
VATNLYGASV ITYSSIARNR IKLIEKMGIT HYPVCIAKTQ YSFSADPKIY 500
GAVNNFEFHI KDIVINNGAE MIVAIAGEIL RMPGLPKEPQ ALHIDIVDGE 550
IEGLS 555
Length:555
Mass (Da):60,482
Last modified:June 1, 2003 - v1
Checksum:i2E9B6E45357D0F8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO75844.1.
RefSeqiNP_809650.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO75844; AAO75844; BT_0737.
GeneIDi1073612.
KEGGibth:BT_0737.
PATRICi21056263. VBIBacThe70966_0752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO75844.1 .
RefSeqi NP_809650.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8A9S8.
SMRi Q8A9S8. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_0737.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO75844 ; AAO75844 ; BT_0737 .
GeneIDi 1073612.
KEGGi bth:BT_0737.
PATRICi 21056263. VBIBacThe70966_0752.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi DPKKINA.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BTHE226186:GJXV-745-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiFTHS_BACTN
AccessioniPrimary (citable) accession number: Q8A9S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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