Reviewed, UniProtKB/Swiss-Prot Q8A9S3 (PYRB_BACTN)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BT_0742

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Aspartate carbamoyltransferase		PRO_0000113100

Sequences

	Sequence		Length	Mass (Da)
	Q8A9S3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F46C8838BC58BA47	FASTA	313	36,188
	10 20 30 40 50 60 MENRSLVTIA EHSKEKILYM LEMAKQFEMN PNRRLLQGKV VATLFFEPST RTRLSFETAA 70 80 90 100 110 120 NRLGARVIGF TDPKATSSSK GETLKDTIMM VSSYADIIVM RHYLEGAARY ASEVAPVPIV 130 140 150 160 170 180 NAGDGANQHP SQTMLDLYSI YKTQGTLENL NIFLVGDLKY GRTVHSLLMA MRHFNPTFHF 190 200 210 220 230 240 IAPDELKMPE EYKLYCKEHQ IKYIEHTEFT EEIIADADIL YMTRVQRERF TDLMEYERVK 250 260 270 280 290 300 NVYILRNKML ENTRPNLRIL HPLPRVNEIA YDVDNNPKAY YFQQAQNGLY AREAILCDVL 310 GITLEDVKND ILL

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO75849.1.
RefSeq	NP_809655.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1073579.
GenomeReviews	Gene locus BT_0742 in contig AE015928_GR.
KEGG	bth:BT_0742.
NMPDR	fig|226186.1.peg.742.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A9S3.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_0742-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACTN

Accession

Primary (citable) accession number: Q8A9S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)