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Q8A9M2 (XYLA_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xylose isomerase
EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:BT_0793
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455

Subunit structure

Homotetramer By similarity. HAMAP MF_00455

Subcellular location

Cytoplasm By similarity HAMAP MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylose isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Xylose isomerase HAMAP MF_00455
PRO_0000195768

Sites

Active site1031 By similarity
Active site1061 By similarity
Metal binding2341Magnesium 1 By similarity
Metal binding2701Magnesium 1 By similarity
Metal binding2701Magnesium 2 By similarity
Metal binding2731Magnesium 2 By similarity
Metal binding2981Magnesium 1 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3111Magnesium 2 By similarity
Metal binding3411Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8A9M2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: DDF724888AE5EF71

FASTA43848,938
        10         20         30         40         50         60 
MATKEFFPGI EKIKFEGKDS KNPMAFRYYD AEKVINGKKM KDWLRFAMAW WHTLCAEGGD 

        70         80         90        100        110        120 
QFGGGTKQFP WNGNADAIQA AKDKMDAGFE FMQKMGIEYY CFHDVDLVSE GASVEEYEAN 

       130        140        150        160        170        180 
LKEIVAYAKQ KQAETGIKLL WGTANVFGHA RYMNGAATNP DFDVVARAAV QIKNAIDATI 

       190        200        210        220        230        240 
ELGGENYVFW GGREGYMSLL NTDQKREKEH LAQMLTIARD YARARGFKGT FLIEPKPMEP 

       250        260        270        280        290        300 
TKHQYDVDTE TVIGFLKAHG LDKDFKVNIE VNHATLAGHT FEHELAVAVD NGMLGSIDAN 

       310        320        330        340        350        360 
RGDYQNGWDT DQFPIDNYEL TQAMMQIIRN GGLGTGGTNF DAKTRRNSTD LEDIFIAHIA 

       370        380        390        400        410        420 
GMDAMARALE SAAALLDESP YKKMLADRYA SFDGGKGKEF EDGKLTLEDV VAYAKTKGEP 

       430 
KQTSGKQELY EAILNMYC

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015928 Genomic DNA. Translation: AAO75900.1.
RefSeqNP_809706.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A9M2.
SMRQ8A9M2. Positions 4-438.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1074491.
GenomeReviewsGene locus BT_0793 in contig AE015928_GR.
KEGGbth:BT_0793.
NMPDRfig|226186.1.peg.793.
PATRIC21056383. VBIBacThe70966_0811.

Phylogenomic databases

HOGENOMHBG297199.
OMALLGWDTD.
PhylomeDBQ8A9M2.
ProtClustDBPRK05474.

Enzyme and pathway databases

BioCycBTHE226186:BT_0793-MONOMER.

Family and domain databases

HAMAPMF_00455. Xylose_isom_A.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KOK01805.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMsTIGR02630. Xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_BACTN
AccessionPrimary (citable) accession number: Q8A9M2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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