ID   UXAB_BACTN              Reviewed;         479 AA.
AC   Q8A9J0;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   16-JUN-2009, entry version 41.
DE   RecName: Full=Altronate oxidoreductase;
DE            EC=1.1.1.58;
DE   AltName: Full=Tagaturonate reductase;
DE   AltName: Full=Tagaturonate dehydrogenase;
GN   Name=uxaB; OrderedLocusNames=BT_0825;
OS   Bacteroides thetaiotaomicron.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
RX   MEDLINE=22550858; PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K.,
RA   Chiang H.C., Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- CATALYTIC ACTIVITY: D-altronate + NAD(+) = D-tagaturonate + NADH.
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC       subfamily.
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DR   EMBL; AE015928; AAO75932.1; -; Genomic_DNA.
DR   RefSeq; NP_809738.1; -.
DR   GeneID; 1074221; -.
DR   GenomeReviews; AE015928_GR; BT_0825.
DR   KEGG; bth:BT_0825; -.
DR   NMPDR; fig|226186.1.peg.825; -.
DR   HOGENOM; Q8A9J0; -.
DR   OMA; Q8A9J0; SIFPCEL.
DR   BioCyc; BTHE226186:BT_0825-MON; -.
DR   BRENDA; 1.1.1.58; 21018.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00670; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    479       Altronate oxidoreductase.
FT                                /FTId=PRO_0000170740.
FT   NP_BIND      18     29       NAD (By similarity).
SQ   SEQUENCE   479 AA;  53962 MW;  29F5AFD94429B071 CRC64;
     MKALNKETAP KVQRPERIIQ FGEGNFLRAF VDWIIYNMNQ KTDFNSSVVV VQPIDKGMVD
     MLNAQDDLYH VNLQGLDKGE VVNSLTMIDV ISRALNPYTQ NDEFMKLAEQ PEMRFVISNT
     TEAGIAFDPT CKLEDAPASS YPGKLTQLLY HRFKTFNGDK TKGLIIFPCE LIFLNGHKLK
     ETIYQYIDLW NLGNEFKTWF EEACGVYATL VDRIVPGFPR KDIAAIKEKI QYDDNLVVQA
     EIFHLWVIEA PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGV
     NIVRDACQHE VIGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF VDHAVTSIML
     NSFPKYETRD LPGLKTYLER KGELPKGLVL GLAAIITYYK GGVRADGAEI VPNDAPEIMN
     LLKELWATGC TKKVTEGVLA AEFIWGEDLN KIPGLAAAVK ADLDSIQEKG MLETVKGIL
//