Reviewed, UniProtKB/Swiss-Prot Q8A9J0 (UXAB_BACTN)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	BT_0825

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD(+) = D-tagaturonate + NADH.
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion.
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Altronate oxidoreductase		PRO_0000170740
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8A9J0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 29F5AFD94429B071	FASTA	479	53,962
	10 20 30 40 50 60 MKALNKETAP KVQRPERIIQ FGEGNFLRAF VDWIIYNMNQ KTDFNSSVVV VQPIDKGMVD 70 80 90 100 110 120 MLNAQDDLYH VNLQGLDKGE VVNSLTMIDV ISRALNPYTQ NDEFMKLAEQ PEMRFVISNT 130 140 150 160 170 180 TEAGIAFDPT CKLEDAPASS YPGKLTQLLY HRFKTFNGDK TKGLIIFPCE LIFLNGHKLK 190 200 210 220 230 240 ETIYQYIDLW NLGNEFKTWF EEACGVYATL VDRIVPGFPR KDIAAIKEKI QYDDNLVVQA 250 260 270 280 290 300 EIFHLWVIEA PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGV 310 320 330 340 350 360 NIVRDACQHE VIGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF VDHAVTSIML 370 380 390 400 410 420 NSFPKYETRD LPGLKTYLER KGELPKGLVL GLAAIITYYK GGVRADGAEI VPNDAPEIMN 430 440 450 460 470 LLKELWATGC TKKVTEGVLA AEFIWGEDLN KIPGLAAAVK ADLDSIQEKG MLETVKGIL

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO75932.1.
RefSeq	NP_809738.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1074221.
GenomeReviews	Gene locus BT_0825 in contig AE015928_GR.
KEGG	bth:BT_0825.
NMPDR	fig|226186.1.peg.825.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A9J0.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_0825-MON.
Family and domain databases
HAMAP	MF_00670. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
ProtoNet	Search...

Entry information

Entry name

UXAB_BACTN

Accession

Primary (citable) accession number: Q8A9J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)