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Q8A9J0 (UXAB_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Altronate oxidoreductase

EC=1.1.1.58
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene names
Name:uxaB
Ordered Locus Names:BT_0825
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP-Rule MF_00670

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00670

Sequence similarities

Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

tagaturonate reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Altronate oxidoreductase HAMAP-Rule MF_00670
PRO_0000170740

Regions

Nucleotide binding18 – 2912NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8A9J0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 29F5AFD94429B071

FASTA47953,962
        10         20         30         40         50         60 
MKALNKETAP KVQRPERIIQ FGEGNFLRAF VDWIIYNMNQ KTDFNSSVVV VQPIDKGMVD 

        70         80         90        100        110        120 
MLNAQDDLYH VNLQGLDKGE VVNSLTMIDV ISRALNPYTQ NDEFMKLAEQ PEMRFVISNT 

       130        140        150        160        170        180 
TEAGIAFDPT CKLEDAPASS YPGKLTQLLY HRFKTFNGDK TKGLIIFPCE LIFLNGHKLK 

       190        200        210        220        230        240 
ETIYQYIDLW NLGNEFKTWF EEACGVYATL VDRIVPGFPR KDIAAIKEKI QYDDNLVVQA 

       250        260        270        280        290        300 
EIFHLWVIEA PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGV 

       310        320        330        340        350        360 
NIVRDACQHE VIGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF VDHAVTSIML 

       370        380        390        400        410        420 
NSFPKYETRD LPGLKTYLER KGELPKGLVL GLAAIITYYK GGVRADGAEI VPNDAPEIMN 

       430        440        450        460        470 
LLKELWATGC TKKVTEGVLA AEFIWGEDLN KIPGLAAAVK ADLDSIQEKG MLETVKGIL 

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO75932.1.
RefSeqNP_809738.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A9J0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_0825.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO75932; AAO75932; BT_0825.
GeneID1074221.
KEGGbth:BT_0825.
PATRIC21056449. VBIBacThe70966_0842.

Phylogenomic databases

eggNOGCOG0246.
KOK00041.
OMARFNNPFV.
OrthoDBEOG6CVVB8.
ProtClustDBPRK03643.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-836-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00670. Altron_oxidoreduct.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXAB_BACTN
AccessionPrimary (citable) accession number: Q8A9J0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways