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Q8A9J0

- UXAB_BACTN

UniProt

Q8A9J0 - UXAB_BACTN

Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 2912NADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. tagaturonate reductase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBTHE226186:GJXV-836-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Altronate oxidoreductaseUniRule annotation (EC:1.1.1.58UniRule annotation)
    Alternative name(s):
    Tagaturonate dehydrogenaseUniRule annotation
    Tagaturonate reductaseUniRule annotation
    Gene namesi
    Name:uxaBUniRule annotation
    Ordered Locus Names:BT_0825
    OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
    Taxonomic identifieri226186 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000001414: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Altronate oxidoreductasePRO_0000170740Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226186.BT_0825.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8A9J0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannitol dehydrogenase family. UxaB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0246.
    KOiK00041.
    OMAiHAVTSIM.
    OrthoDBiEOG6CVVB8.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00670. Altron_oxidoreduct.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8A9J0-1 [UniParc]FASTAAdd to Basket

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    MKALNKETAP KVQRPERIIQ FGEGNFLRAF VDWIIYNMNQ KTDFNSSVVV    50
    VQPIDKGMVD MLNAQDDLYH VNLQGLDKGE VVNSLTMIDV ISRALNPYTQ 100
    NDEFMKLAEQ PEMRFVISNT TEAGIAFDPT CKLEDAPASS YPGKLTQLLY 150
    HRFKTFNGDK TKGLIIFPCE LIFLNGHKLK ETIYQYIDLW NLGNEFKTWF 200
    EEACGVYATL VDRIVPGFPR KDIAAIKEKI QYDDNLVVQA EIFHLWVIEA 250
    PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGV 300
    NIVRDACQHE VIGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF 350
    VDHAVTSIML NSFPKYETRD LPGLKTYLER KGELPKGLVL GLAAIITYYK 400
    GGVRADGAEI VPNDAPEIMN LLKELWATGC TKKVTEGVLA AEFIWGEDLN 450
    KIPGLAAAVK ADLDSIQEKG MLETVKGIL 479
    Length:479
    Mass (Da):53,962
    Last modified:June 1, 2003 - v1
    Checksum:i29F5AFD94429B071
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO75932.1.
    RefSeqiNP_809738.1. NC_004663.1.

    Genome annotation databases

    EnsemblBacteriaiAAO75932; AAO75932; BT_0825.
    GeneIDi1074221.
    KEGGibth:BT_0825.
    PATRICi21056449. VBIBacThe70966_0842.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO75932.1 .
    RefSeqi NP_809738.1. NC_004663.1.

    3D structure databases

    ProteinModelPortali Q8A9J0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226186.BT_0825.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO75932 ; AAO75932 ; BT_0825 .
    GeneIDi 1074221.
    KEGGi bth:BT_0825.
    PATRICi 21056449. VBIBacThe70966_0842.

    Phylogenomic databases

    eggNOGi COG0246.
    KOi K00041.
    OMAi HAVTSIM.
    OrthoDBi EOG6CVVB8.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci BTHE226186:GJXV-836-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00670. Altron_oxidoreduct.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
      Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
      Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

    Entry informationi

    Entry nameiUXAB_BACTN
    AccessioniPrimary (citable) accession number: Q8A9J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3