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Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 2912NADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-836-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductaseUniRule annotation (EC:1.1.1.58UniRule annotation)
Alternative name(s):
Tagaturonate dehydrogenaseUniRule annotation
Tagaturonate reductaseUniRule annotation
Gene namesi
Name:uxaBUniRule annotation
Ordered Locus Names:BT_0825
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Altronate oxidoreductasePRO_0000170740Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_0825.

Structurei

3D structure databases

ProteinModelPortaliQ8A9J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family. UxaB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0246.
InParanoidiQ8A9J0.
KOiK00041.
OMAiRFNNPFV.
OrthoDBiEOG6CVVB8.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023668. Altronate_OxRdtase.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A9J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALNKETAP KVQRPERIIQ FGEGNFLRAF VDWIIYNMNQ KTDFNSSVVV
60 70 80 90 100
VQPIDKGMVD MLNAQDDLYH VNLQGLDKGE VVNSLTMIDV ISRALNPYTQ
110 120 130 140 150
NDEFMKLAEQ PEMRFVISNT TEAGIAFDPT CKLEDAPASS YPGKLTQLLY
160 170 180 190 200
HRFKTFNGDK TKGLIIFPCE LIFLNGHKLK ETIYQYIDLW NLGNEFKTWF
210 220 230 240 250
EEACGVYATL VDRIVPGFPR KDIAAIKEKI QYDDNLVVQA EIFHLWVIEA
260 270 280 290 300
PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGV
310 320 330 340 350
NIVRDACQHE VIGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF
360 370 380 390 400
VDHAVTSIML NSFPKYETRD LPGLKTYLER KGELPKGLVL GLAAIITYYK
410 420 430 440 450
GGVRADGAEI VPNDAPEIMN LLKELWATGC TKKVTEGVLA AEFIWGEDLN
460 470
KIPGLAAAVK ADLDSIQEKG MLETVKGIL
Length:479
Mass (Da):53,962
Last modified:June 1, 2003 - v1
Checksum:i29F5AFD94429B071
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75932.1.
RefSeqiNP_809738.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO75932; AAO75932; BT_0825.
GeneIDi1074221.
KEGGibth:BT_0825.
PATRICi21056449. VBIBacThe70966_0842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO75932.1.
RefSeqiNP_809738.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8A9J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_0825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO75932; AAO75932; BT_0825.
GeneIDi1074221.
KEGGibth:BT_0825.
PATRICi21056449. VBIBacThe70966_0842.

Phylogenomic databases

eggNOGiCOG0246.
InParanoidiQ8A9J0.
KOiK00041.
OMAiRFNNPFV.
OrthoDBiEOG6CVVB8.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciBTHE226186:GJXV-836-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023668. Altronate_OxRdtase.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiUXAB_BACTN
AccessioniPrimary (citable) accession number: Q8A9J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.