Reviewed, UniProtKB/Swiss-Prot Q8A9E3 (SYD_BACTN)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BT_0872

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	587 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00044
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 587	587	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_0000110830

Sequences

	Sequence		Length	Mass (Da)
	Q8A9E3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 09D82A4A57016A29	FASTA	587	66,563
	10 20 30 40 50 60 MFRTHTCGEL RISDVNKQIT LSGWVQRSRK MGGMTFIDLR DRYGITQLVF NEEINAELCD 70 80 90 100 110 120 RANKLGREFV IQITGTVNER FSKNANIPTG DIEIIVSELN VLNTAMTPPF TIEDNTDGGD 130 140 150 160 170 180 DIRMKYRYLD LRRNAVRSNL ELRHKMTIEV RKYLDSLGFI EVETPVLIGS TPEGARDFVV 190 200 210 220 230 240 PSRMNPGQFY ALPQSPQTLK QLLMVSGFDR YFQIAKCFRD EDLRADRQPE FTQIDCEMSF 250 260 270 280 290 300 VEQEDIISTF EGMAKHLFKT LRGVELTEPF QRMPWADAMK YYGSDKPDLR FGMKFVELMD 310 320 330 340 350 360 IMKGHGFSVF DNAAYVGGIC AEGAATYTRK QLDALTEFVK KPQIGAKGMV YARVEADGTV 370 380 390 400 410 420 KSSVDKFYTQ EVLQQMKEAF GAKPGDLILI LSGDDVMKTR KQLCELRLEM GSQLGLRDKN 430 440 450 460 470 480 KFVCLWVIDF PMFEWSEEEG RLMAMHHPFT HPKEEDIPLL DTDPAAVRAD AYDMVVNGVE 490 500 510 520 530 540 VGGGSIRIHD AQLQARMFEI LGFTPEKAQA QFGFLMNAFK YGAPPHGGLA YGLDRWVSLF 550 560 570 580 AGLDSIRDCI AFPKNNSGRD VMLDAPSEID QTQLDELNLI VDIKENK

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO75979.1.
RefSeq	NP_809785.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1073405.
GenomeReviews	Gene locus BT_0872 in contig AE015928_GR.
KEGG	bth:BT_0872.
NMPDR	fig|226186.1.peg.872.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A9E3.
OMA	VDRRRDH.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_0872-MON.
BRENDA	6.1.1.12. 21018.
Family and domain databases
HAMAP	MF_00044. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR002312. Asp-tRNA-synth_IIb. IPR020564. Asp-tRNA-synth_IIb_bac-type. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BACTN

Accession

Primary (citable) accession number: Q8A9E3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)