ID   TRMD_BACTN              Reviewed;         225 AA.
AC   Q8A9C2;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   16-JUN-2009, entry version 44.
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.31;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD; OrderedLocusNames=BT_0893;
OS   Bacteroides thetaiotaomicron.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
RX   MEDLINE=22550858; PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K.,
RA   Chiang H.C., Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(1)-methylguanine.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase trmD family.
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DR   EMBL; AE015928; AAO76000.1; -; Genomic_DNA.
DR   RefSeq; NP_809806.1; -.
DR   GeneID; 1073262; -.
DR   GenomeReviews; AE015928_GR; BT_0893.
DR   KEGG; bth:BT_0893; -.
DR   NMPDR; fig|226186.1.peg.893; -.
DR   HOGENOM; Q8A9C2; -.
DR   OMA; Q8A9C2; HRSVDDT.
DR   BioCyc; BTHE226186:BT_0893-MON; -.
DR   BRENDA; 2.1.1.31; 21018.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0009019; F:tRNA (guanine-N1-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_00605; -; 1.
DR   InterPro; IPR016009; tRNA_m1G_MeTrfase.
DR   InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PIRSF; PIRSF000386; tRNA_mtase; 1.
DR   ProDom; PD004978; tRNA_m1G_mtfrase; 1.
DR   TIGRFAMs; TIGR00088; trmD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing.
FT   CHAIN         1    225       tRNA (guanine-N(1)-)-methyltransferase.
FT                                /FTId=PRO_0000060330.
FT   REGION      132    137       S-adenosyl-L-methionine binding (By
FT                                similarity).
FT   BINDING     112    112       S-adenosyl-L-methionine; via amide
FT                                nitrogen (By similarity).
SQ   SEQUENCE   225 AA;  25558 MW;  0B49CF62E2AC9E71 CRC64;
     MRIDIITVLP EMIEGFFNCS IMKRAQNKGL AEIHIHNLRD YTEDKYRRVD DYPFGGFAGM
     VMKIEPIERC INALKAERDY DEVIFTTPDG EQFNQPMANS LSLAQNLIIL CGHFKGIDYR
     IREHLITKEI SIGDYVLTGG ELAAAVMADA IVRIIPGVIS DEQSALSDSF QDNLLAAPVY
     TRPADYKGWK VPDILLSGHE AKIKEWELQQ SLERTKKLRP DLLED
//