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Q8A908 (Q8A908_BACTN) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Dihydroorotate dehydrogenase EMBL AAO76116.1
Gene names
Ordered Locus Names:BT_1009
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity. SAAS SAAS012135

Catalytic activity

(S)-dihydroorotate + a quinone = orotate + a quinol. SAAS SAAS012135

Cofactor

Binds 1 FMN per subunit By similarity. SAAS SAAS012135

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. SAAS SAAS012135

Subunit structure

Monomer By similarity. SAAS SAAS012135

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1581Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
Q8A908 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 47F42DEEA6D2EFCF

FASTA31235,188
        10         20         30         40         50         60 
MLLNWLRIYR YLLPVRACVR GHYQVDEPFS YGSLRFKNRI GLSAGFDKNA ETFDELADFG 

        70         80         90        100        110        120 
FGFLEVGTVT PDYQPGNPSS RIFRLVEDES LISRTGFNNC GVDVALAHIR RHRKHSYILG 

       130        140        150        160        170        180 
VNINKNPLSV GEQIIKDFEL VFTRLYESVD YFTLNWGSID KESFAKVLEN FTTFREAVNK 

       190        200        210        220        230        240 
RCSIFIKLPA DIDEKELDLV ISLAYKYSIE GFIATGPTMD RSELHQTKTK QLEKIGNGGV 

       250        260        270        280        290        300 
SGRGIGKKSQ KVVHYLSEHT DRHFLIIGAG GIMTAEDAAD MISQGADMVQ IYSAFIYSGP 

       310 
SVVHKIGKKL KH

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References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015928 Genomic DNA. Translation: AAO76116.1.
RefSeqNP_809922.1. NC_004663.1.

3D structure databases

HSSPHSSP built from PDB template 1D3G based on UniProtKB Q02127.
ProteinModelPortalQ8A908.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1074263.
GenomeReviewsGene locus BT_1009 in contig AE015928_GR.
KEGGbth:BT_1009.
NMPDRfig|226186.1.peg.1009.
PATRIC21056829. VBIBacThe70966_1025.

Phylogenomic databases

HOGENOMHBG351027.
OMASYVTVNI.
PhylomeDBQ8A908.
ProtClustDBPRK05286.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01036. PyrD_sub2. 1 hit.
PROSITEPS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8A908_BACTN
AccessionPrimary (citable) accession number: Q8A908
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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