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Q8A8R5

- PFKA1_BACTN

UniProt

Q8A8R5 - PFKA1_BACTN

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Protein
ATP-dependent 6-phosphofructokinase 1
Gene
pfkA1, BT_1102
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotation

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131ATP; via amide nitrogen By similarity
Metal bindingi105 – 1051Magnesium; catalytic By similarity
Active sitei130 – 1301Proton acceptor By similarity
Binding sitei157 – 1571Allosteric activator ADP By similarity
Binding sitei165 – 1651Substrate; shared with dimeric partner By similarity
Binding sitei214 – 2141Allosteric activator ADP By similarity
Binding sitei225 – 2251Substrate By similarity
Binding sitei251 – 2511Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 752ATP By similarity
Nucleotide bindingi104 – 1074ATP By similarity

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-1121-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinase 1 (EC:2.7.1.11)
Short name:
ATP-PFK 1
Short name:
Phosphofructokinase 1
Alternative name(s):
Phosphohexokinase 1
Gene namesi
Name:pfkA1
Ordered Locus Names:BT_1102
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327ATP-dependent 6-phosphofructokinase 1UniRule annotation
PRO_0000111937Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_1102.

Structurei

3D structure databases

ProteinModelPortaliQ8A8R5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 275Allosteric activator ADP binding; shared with dimeric partner By similarity
Regioni128 – 1303Substrate binding By similarity
Regioni172 – 1743Substrate binding By similarity
Regioni188 – 1903Allosteric activator ADP binding By similarity
Regioni216 – 2183Allosteric activator ADP binding By similarity
Regioni257 – 2604Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0205.
KOiK00850.
OMAiNVMIGIR.
OrthoDBiEOG644ZRM.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase_I_B1.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8A8R5-1 [UniParc]FASTAAdd to Basket

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MDNKYIGILT SGGDASGMNA AIRAVTRAAI FNGFKVKGIY RGYEGLIAGE    50
VKELTTEDVS SIIQRGGTIL KTARSETFTT PEGRKKAYKV IQKENINALI 100
IIGGDGSLTG ARIFAEEYDV TCIGLPGTID NDLYGTDFTI GYDTALNTIV 150
ECVDKIRDTA TSHDRIFFVE VMGRDAGFLA QNSAIASGAE AAIIPEDRTD 200
VDQLETFIGR GFRKTKNSSI VIVTESPENK NGGAIYYADR VKKEYPGYDV 250
RVSILGHLQR GGAPSANDRI LASRLGEAAI QALMEGQRNV MIGIRNNEIV 300
YVPFVQAIKK DKPIDKSLIR VLNELSI 327
Length:327
Mass (Da):35,511
Last modified:June 16, 2003 - v1
Checksum:iAD8900CDDF1B5479
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO76209.1.
RefSeqiNP_810015.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO76209; AAO76209; BT_1102.
GeneIDi1073299.
KEGGibth:BT_1102.
PATRICi21057033. VBIBacThe70966_1126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO76209.1 .
RefSeqi NP_810015.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8A8R5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 226186.BT_1102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO76209 ; AAO76209 ; BT_1102 .
GeneIDi 1073299.
KEGGi bth:BT_1102.
PATRICi 21057033. VBIBacThe70966_1126.

Phylogenomic databases

eggNOGi COG0205.
KOi K00850.
OMAi NVMIGIR.
OrthoDBi EOG644ZRM.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci BTHE226186:GJXV-1121-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase_I_B1.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiPFKA1_BACTN
AccessioniPrimary (citable) accession number: Q8A8R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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