Reviewed, UniProtKB/Swiss-Prot Q8A8R2 (GPMA1_BACTN)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1
      Short name=Phosphoglyceromutase 1
      Short name=PGAM 1
      Short name=BPG-dependent PGAM 1
      Short name=dPGM 1
    EC=5.4.2.1

Gene names

Name:	gpmA1
Ordered Locus Names:	BT_1105

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 HAMAP MF_01039		PRO_0000179846
Sites
	Active site	9	1	Tele-phosphohistidine intermediate By similarity
	Active site	182	1	By similarity
	Site	60	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8A8R2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A4B8AE020DF031AB	FASTA	249	28,420
	10 20 30 40 50 60 MKRIVLLRHG ESLWNKENRF TGWTDVDLSE KGVEEACKAG DALREAGFSF EAAYTSYLKR 70 80 90 100 110 120 AVKTLNCVLD RLDKDWIPVE KTWRLNEKHY GMLQGLNKSE TAVQYGEEQV HIWRRSYDVA 130 140 150 160 170 180 PAPVGKDDPR NPGMDIRYAG VPDSELPRTE SLKDTIGRVM PYWKCIIFPA LMYKDSLLVV 190 200 210 220 230 240 AHGNSLRGII KHLKGISDTD ISNLNLPTAV PYVFEFDDRL VLVKDYYLGN PEEIRKRAEA VAKQGMAKK

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO76212.1.
RefSeq	NP_810018.1.
3D structure databases
HSSP	HSSP built from PDB template 1E58 based on UniProtKB P31217.
ModBase	Search...
Genome annotation databases
GeneID	1073267.
GenomeReviews	Gene locus BT_1105 in contig AE015928_GR.
KEGG	bth:BT_1105.
NMPDR	fig|226186.1.peg.1105.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A8R2.
OMA	PMRFLGD.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_1105-MON.
BRENDA	5.4.2.1. 21018.
Family and domain databases
HAMAP	MF_01039. [Tree]
InterPro	IPR001345. PG/BPGM_mutase_AC. IPR013078. PG_mutase. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA1_BACTN

Accession

Primary (citable) accession number: Q8A8R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)