Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-1166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:BT_1147
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_0000166903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_1147.

Structurei

3D structure databases

ProteinModelPortaliQ8A8M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
InParanoidiQ8A8M0.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A8M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDLLASRH IGINEEDTAV MLRKIGVDSL DELINKTIPA NIRLKEPLAL
60 70 80 90 100
AKPLTEYEFG KHIADLASKN KLYTTYIGLG WYNTITPAVI QRNVFENPVW
110 120 130 140 150
YTSYTPYQTE VSQGRLEALM NFQTAVCDLT AMPLANCSLL DEATAAAEAV
160 170 180 190 200
TMMYALRSRT QQKAGANVVF VDENIFPQTL AVMTTRAIPQ GIELRVGKYK
210 220 230 240 250
EFEPSPEIFA CILQYPNSSG NVEDYADFTK KAHEADCKVA VAADILSLAL
260 270 280 290 300
LTPPGEWGAD IVFGTTQRLG TPMFYGGPSA GYFATRDEYK RNMPGRIIGW
310 320 330 340 350
SKDKYGKLCY RMALQTREQH IKREKATSNI CTAQALLATM AGFYAVYHGQ
360 370 380 390 400
EGIKTIASRI HSITVFLDKQ LKKFGYTQVN AQYFDTLRFE LPEHVSAQQI
410 420 430 440 450
RTIALSKEVN LRYYENGDVG FSIDETTDIA ATNVLLSIFA IAAGKDYQKV
460 470 480 490 500
EDVPEKSNID KALKRTTPFL THEVFSNYHT ETEMMRYIKR LDRKDISLAQ
510 520 530 540 550
SMISLGSCTM KLNAAAEMLP LSRPEFMSMH PLVPEDQAEG YRELISNLSE
560 570 580 590 600
DLKVITGFAG VSLQPNSGAA GEYAGLRVIR AYLESIGQGH RNKILIPASA
610 620 630 640 650
HGTNPASAIQ AGFETVTCAC DEQGNVDMGD LRAKAEENKE ALAALMITYP
660 670 680 690 700
STHGIFETEI KEICEIIHAC GAQVYMDGAN MNAQVGLTNP GFIGADVCHL
710 720 730 740 750
NLHKTFASPH GGGGPGVGPI CVAEHLVPFL PGHSIFGSTQ NQVSAAPFGS
760 770 780 790 800
AGILPITYGY IRMMGTEGLT QATKIAILNA NYLAACLKDT YGIVYRGATG
810 820 830 840 850
FVGHEMILEC RKVHEETGIS ENDIAKRLMD YGYHAPTLSF PVHGTLMIEP
860 870 880 890 900
TESESLAELD NFVDVMLNIW KEIQEVKNEE ADKNDNVLIN APHPEYEIVN
910 920 930 940
DNWEHSYTRE KAAYPIESVR ENKFWVNVAR VDNTLGDRKL LPTRYGTFE
Length:949
Mass (Da):104,967
Last modified:June 1, 2003 - v1
Checksum:i90222CFA46E06AE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO76254.1.
RefSeqiNP_810060.1. NC_004663.1.
WP_008765866.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO76254; AAO76254; BT_1147.
GeneIDi1072231.
KEGGibth:BT_1147.
PATRICi21057119. VBIBacThe70966_1169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO76254.1.
RefSeqiNP_810060.1. NC_004663.1.
WP_008765866.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8A8M0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_1147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO76254; AAO76254; BT_1147.
GeneIDi1072231.
KEGGibth:BT_1147.
PATRICi21057119. VBIBacThe70966_1169.

Phylogenomic databases

eggNOGiCOG1003.
InParanoidiQ8A8M0.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-1166-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiGCSP_BACTN
AccessioniPrimary (citable) accession number: Q8A8M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.