SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8A8M0

- GCSP_BACTN

UniProt

Q8A8M0 - GCSP_BACTN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, BT_1147
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-1166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BT_1147
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi226186.BT_1147.

Structurei

3D structure databases

ProteinModelPortaliQ8A8M0.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiTHRNIAL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A8M0-1 [UniParc]FASTAAdd to Basket

« Hide

MKTDLLASRH IGINEEDTAV MLRKIGVDSL DELINKTIPA NIRLKEPLAL    50
AKPLTEYEFG KHIADLASKN KLYTTYIGLG WYNTITPAVI QRNVFENPVW 100
YTSYTPYQTE VSQGRLEALM NFQTAVCDLT AMPLANCSLL DEATAAAEAV 150
TMMYALRSRT QQKAGANVVF VDENIFPQTL AVMTTRAIPQ GIELRVGKYK 200
EFEPSPEIFA CILQYPNSSG NVEDYADFTK KAHEADCKVA VAADILSLAL 250
LTPPGEWGAD IVFGTTQRLG TPMFYGGPSA GYFATRDEYK RNMPGRIIGW 300
SKDKYGKLCY RMALQTREQH IKREKATSNI CTAQALLATM AGFYAVYHGQ 350
EGIKTIASRI HSITVFLDKQ LKKFGYTQVN AQYFDTLRFE LPEHVSAQQI 400
RTIALSKEVN LRYYENGDVG FSIDETTDIA ATNVLLSIFA IAAGKDYQKV 450
EDVPEKSNID KALKRTTPFL THEVFSNYHT ETEMMRYIKR LDRKDISLAQ 500
SMISLGSCTM KLNAAAEMLP LSRPEFMSMH PLVPEDQAEG YRELISNLSE 550
DLKVITGFAG VSLQPNSGAA GEYAGLRVIR AYLESIGQGH RNKILIPASA 600
HGTNPASAIQ AGFETVTCAC DEQGNVDMGD LRAKAEENKE ALAALMITYP 650
STHGIFETEI KEICEIIHAC GAQVYMDGAN MNAQVGLTNP GFIGADVCHL 700
NLHKTFASPH GGGGPGVGPI CVAEHLVPFL PGHSIFGSTQ NQVSAAPFGS 750
AGILPITYGY IRMMGTEGLT QATKIAILNA NYLAACLKDT YGIVYRGATG 800
FVGHEMILEC RKVHEETGIS ENDIAKRLMD YGYHAPTLSF PVHGTLMIEP 850
TESESLAELD NFVDVMLNIW KEIQEVKNEE ADKNDNVLIN APHPEYEIVN 900
DNWEHSYTRE KAAYPIESVR ENKFWVNVAR VDNTLGDRKL LPTRYGTFE 949
Length:949
Mass (Da):104,967
Last modified:June 1, 2003 - v1
Checksum:i90222CFA46E06AE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO76254.1.
RefSeqiNP_810060.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO76254; AAO76254; BT_1147.
GeneIDi1072231.
KEGGibth:BT_1147.
PATRICi21057119. VBIBacThe70966_1169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO76254.1 .
RefSeqi NP_810060.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8A8M0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_1147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO76254 ; AAO76254 ; BT_1147 .
GeneIDi 1072231.
KEGGi bth:BT_1147.
PATRICi 21057119. VBIBacThe70966_1169.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi THRNIAL.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BTHE226186:GJXV-1166-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiGCSP_BACTN
AccessioniPrimary (citable) accession number: Q8A8M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi