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Protein

Histidine biosynthesis bifunctional protein HisIE

Gene

hisI

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE:G13PU-6306-MONOMER
UniPathwayiUPA00031; UER00007
UPA00031; UER00008

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine biosynthesis bifunctional protein HisIEUniRule annotation
Including the following 2 domains:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
Short name:
PRA-CHUniRule annotation
Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
Short name:
PRA-PHUniRule annotation
Gene namesi
Name:hisIUniRule annotation
Synonyms:hisIEUniRule annotation
Ordered Locus Names:BT_1377
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001364041 – 203Histidine biosynthesis bifunctional protein HisIEAdd BLAST203

Proteomic databases

PaxDbiQ8A7Z7
PRIDEiQ8A7Z7

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_1377

Structurei

3D structure databases

ProteinModelPortaliQ8A7Z7
SMRiQ8A7Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 108Phosphoribosyl-AMP cyclohydrolaseAdd BLAST108
Regioni109 – 203Phosphoribosyl-ATP pyrophosphohydrolaseAdd BLAST95

Sequence similaritiesi

In the N-terminal section; belongs to the PRA-CH family.UniRule annotation
In the C-terminal section; belongs to the PRA-PH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K8F Bacteria
COG0139 LUCA
COG0140 LUCA
HOGENOMiHOG000277503
InParanoidiQ8A7Z7
KOiK11755
OMAiVMACKDD
OrthoDBiPOG091H050E

Family and domain databases

CDDicd11534 NTP-PPase_HisIE_like, 1 hit
Gene3Di3.10.20.400, 1 hit
HAMAPiMF_01020 HisE, 1 hit
MF_01019 HisIE, 1 hit
InterProiView protein in InterPro
IPR023019 His_synth_HisIE
IPR008179 HisE
IPR021130 PRib-ATP_PPHydrolase-like
IPR002496 PRib_AMP_CycHydrolase_dom
IPR038019 PRib_AMP_CycHydrolase_sf
PfamiView protein in Pfam
PF01502 PRA-CH, 1 hit
PF01503 PRA-PH, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002610 PRA_CycHdrlase, 1 hit
SUPFAMiSSF141734 SSF141734, 1 hit
TIGRFAMsiTIGR03188 histidine_hisI, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A7Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELDFDKMNG LVPAIIQDNE TRKVLMLGFM NKEAYDKTVE TGKVTFFSRT
60 70 80 90 100
KNRLWTKGEE SGNFLHVVSI KADCDNDTLL IQADPAGPVC HTGTDTCWGE
110 120 130 140 150
KNEEPVMFLK ALQDFIDKRH EEMPQGSYTT SLFESGINKI AQKVGEEAVE
160 170 180 190 200
TVIEATNGTN ERLIYEGADL IYHMIVLLTS KGYRIEDLAR ELQERHSSTW

KKH
Length:203
Mass (Da):23,078
Last modified:June 1, 2003 - v1
Checksum:i451226871EA0A2A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO76484.1
RefSeqiNP_810290.1, NC_004663.1
WP_008762399.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO76484; AAO76484; BT_1377
GeneIDi1072959
31616339
KEGGibth:BT_1377
PATRICifig|226186.12.peg.1412

Similar proteinsi

Entry informationi

Entry nameiHIS2_BACTN
AccessioniPrimary (citable) accession number: Q8A7Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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