Q8A7U2 (UXUA_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	BT_1432

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Mannonate dehydratase HAMAP MF_00106		PRO_0000170665

Sequences

	Sequence		Length	Mass (Da)
	Q8A7U2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 49AF971B14104B8E	FASTA	389	44,460
	10 20 30 40 50 60 MYLCEQTWRW YGPNDPVSLW DIKQAGATGI VNALHHIPNG EVWTVEEIMK RKQMIEEVGL 70 80 90 100 110 120 TWSVVESVPV HEHIKTQTGE YLKYIENYKE SIRNLAKCGV MVVTYNFMPV LDWTRTDLAY 130 140 150 160 170 180 TMPDGSKALR FEKAAFLAFD LFILKRPNAE KDYTPEEIAK AKARFEQMSE DDKKLLVRNM 190 200 210 220 230 240 IAGLPGSEES FTVEQFQEAL DRYNDIDAEK LRSNLIFFLK EIAPVADEVG VKLVIHPDDP 250 260 270 280 290 300 PYTILGLPRI LSTEEDFKKL IEAVPNESNG LCLCTGSFGV RADNDLAGMM ERFGDRVNFV 310 320 330 340 350 360 HLRSTQRDEE GNFYEANHLE GNVDMYNVMK SLILLQQRRK CSIAMRPDHG HQMIDDLKKK 370 380 TNPGYSCLGR LRGLAELRGL EMGIAKSIL

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO76539.1.
RefSeq	NP_810345.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A7U2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1071708.
GenomeReviews	Gene locus BT_1432 in contig AE015928_GR.
KEGG	bth:BT_1432.
NMPDR	fig|226186.1.peg.1432.
PATRIC	21057729. VBIBacThe70966_1464.
Phylogenomic databases
HOGENOM	HBG585927.
OMA	VHEEIKT.
PhylomeDB	Q8A7U2.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_1432-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BACTN

Accession

Primary (citable) accession number: Q8A7U2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program