Q8A7H0 (Q8A7H0_BACTN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183

Gene names

Ordered Locus Names:

BT_1554

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183
Pathway	Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183
Sequence similarities	Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
Ligand	NAD PIRNR PIRNR000183
Molecular function	Oxidoreductase PIRNR PIRNR000183
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	alanine dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8A7H0 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 60001165B6148EC7	FASTA	368	39,435
	10 20 30 40 50 60 MIIGVPKEIK NNENRVGMTP SGVAEVVKQG HQVYIQHTAG INSGFPDEAY LSVGAQVLPT 70 80 90 100 110 120 IEDVYATADM IVKVKEPIAP EYHLIRKGQL LFTYFHFASD KELTLAMIDN KSICLAYETV 130 140 150 160 170 180 EKEDHSLPLL IPMSEVAGRM SIQEGARFLE KPQGGKGILL GGVPGVKPAK VLILGGGIVG 190 200 210 220 230 240 SNAAQMAAGM GADVTVADIN LSRLRYLSET LPKNVKTLYA SELRIKKELP DVDLVIGSVL 250 260 270 280 290 300 IPGDKAPHLI TRNILAMMQP GTVLVDVAID QGGCFETSHP TTHSAPTYVI DGIVHYAVAN 310 320 330 340 350 360 IPGAVPYTST LALTNATLPY VIALANKGWK KACKDDPALA LGLNVVEGKV VYKAVADVFD LKYENINL

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO76661.1.
RefSeq	NP_810467.1. NC_004663.1.
3D structure databases
HSSP	HSSP built from PDB template 1SAY based on UniProtKB O52942.
ProteinModelPortal	Q8A7H0.
SMR	Q8A7H0. Positions 1-360.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1076073.
GenomeReviews	Gene locus BT_1554 in contig AE015928_GR.
KEGG	bth:BT_1554.
NMPDR	fig|226186.1.peg.1554.
PATRIC	21057977. VBIBacThe70966_1588.
Phylogenomic databases
HOGENOM	HBG289735.
OMA	VAHGHEV.
PhylomeDB	Q8A7H0.
ProtClustDB	CLSK822772.
Family and domain databases
InterPro	IPR008143. Ala_DH/PNT_CS2. IPR008141. Ala_DH/Pyr_transHydgase. IPR007886. AlaDH/PNT_N. IPR007698. AlaDH/PNT_NAD(H)-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00259.
PANTHER	PTHR10160:SF3. PTHR10160:SF3. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
PIRSF	PIRSF000183. Alanine_dh. 1 hit.
SMART	SM01002. AlaDh_PNT_C. 1 hit. SM01003. AlaDh_PNT_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00518. AlaDH. 1 hit.
PROSITE	PS00837. ALADH_PNT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8A7H0_BACTN

Accession

Primary (citable) accession number: Q8A7H0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)