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Q8A753

- PGK_BACTN

UniProt

Q8A753 - PGK_BACTN

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Protein

Phosphoglycerate kinase

Gene
pgk, BT_1672
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351Substrate By similarity
Binding sitei116 – 1161Substrate By similarity
Binding sitei172 – 1721Substrate By similarity
Binding sitei225 – 2251ATP By similarity
Binding sitei316 – 3161ATP; via carbonyl oxygen By similarity
Binding sitei347 – 3471ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi376 – 3794ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-1705-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:BT_1672
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Phosphoglycerate kinaseUniRule annotationPRO_0000145906Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_1672.

Structurei

3D structure databases

ProteinModelPortaliQ8A753.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 213Substrate binding By similarity
Regioni58 – 614Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OMAiFNVPLRE.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A753-1 [UniParc]FASTAAdd to Basket

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MQTIDKFNFA GKKAFVRVDF NVPLDENFNI TDDTRMRAAL PTLKKILADG    50
GSIIIGSHLG RPKGVADKFS LKHIIKHLSE LLGVEVQFAN DCMGEEAAVK 100
AAALQPGEVL LLENLRFYAE EEGKPRGLAE DATDEEKAAA KKAVKESQKE 150
FTKKLASYAD CYVNDAFGTA HRAHASTALI AKYFDTDNKM FGYLMEKEVK 200
AVDKVLNDIQ RPFTAIMGGS KVSSKIEIIE NLLNKVDNLI IAGGMTYTFT 250
KAMGGKIGIS ICEDDKLDLA LDLIKKAKEK GVNLVLAVDA KIADAFSNDA 300
NTQFCAVDEI PDGWEGLDIG PKTEEIFANV IKESKTILWN GPTGVFEFEN 350
FTHGSRTVGE AIVEATKNGA FSLVGGGDSV ACVNKFGLAS GVSYVSTGGG 400
ALLEAIEGKV LPGIAAINE 419
Length:419
Mass (Da):45,026
Last modified:June 1, 2003 - v1
Checksum:iA99CE14623D7BA31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO76779.1.
RefSeqiNP_810585.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO76779; AAO76779; BT_1672.
GeneIDi1075584.
KEGGibth:BT_1672.
PATRICi21058238. VBIBacThe70966_1714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO76779.1 .
RefSeqi NP_810585.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8A753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_1672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO76779 ; AAO76779 ; BT_1672 .
GeneIDi 1075584.
KEGGi bth:BT_1672.
PATRICi 21058238. VBIBacThe70966_1714.

Phylogenomic databases

eggNOGi COG0126.
KOi K00927.
OMAi FNVPLRE.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci BTHE226186:GJXV-1705-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiPGK_BACTN
AccessioniPrimary (citable) accession number: Q8A753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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