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Q8A753 (PGK_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:BT_1672
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145906

Regions

Nucleotide binding376 – 3794ATP By similarity
Region19 – 213Substrate binding By similarity
Region58 – 614Substrate binding By similarity

Sites

Binding site351Substrate By similarity
Binding site1161Substrate By similarity
Binding site1721Substrate By similarity
Binding site2251ATP By similarity
Binding site3161ATP; via carbonyl oxygen By similarity
Binding site3471ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8A753 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A99CE14623D7BA31

FASTA41945,026
        10         20         30         40         50         60 
MQTIDKFNFA GKKAFVRVDF NVPLDENFNI TDDTRMRAAL PTLKKILADG GSIIIGSHLG 

        70         80         90        100        110        120 
RPKGVADKFS LKHIIKHLSE LLGVEVQFAN DCMGEEAAVK AAALQPGEVL LLENLRFYAE 

       130        140        150        160        170        180 
EEGKPRGLAE DATDEEKAAA KKAVKESQKE FTKKLASYAD CYVNDAFGTA HRAHASTALI 

       190        200        210        220        230        240 
AKYFDTDNKM FGYLMEKEVK AVDKVLNDIQ RPFTAIMGGS KVSSKIEIIE NLLNKVDNLI 

       250        260        270        280        290        300 
IAGGMTYTFT KAMGGKIGIS ICEDDKLDLA LDLIKKAKEK GVNLVLAVDA KIADAFSNDA 

       310        320        330        340        350        360 
NTQFCAVDEI PDGWEGLDIG PKTEEIFANV IKESKTILWN GPTGVFEFEN FTHGSRTVGE 

       370        380        390        400        410 
AIVEATKNGA FSLVGGGDSV ACVNKFGLAS GVSYVSTGGG ALLEAIEGKV LPGIAAINE 

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO76779.1.
RefSeqNP_810585.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A753.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_1672.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO76779; AAO76779; BT_1672.
GeneID1075584.
KEGGbth:BT_1672.
PATRIC21058238. VBIBacThe70966_1714.

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAFNVPLRE.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-1705-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_BACTN
AccessionPrimary (citable) accession number: Q8A753
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways