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Protein

Guanylate kinase

Gene

gmk

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 32ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE:G13PU-6950-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:BT_2009
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001704991 – 204Guanylate kinaseAdd BLAST204

Proteomic databases

PaxDbiQ8A677
PRIDEiQ8A677

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_2009

Structurei

3D structure databases

ProteinModelPortaliQ8A677
SMRiQ8A677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 198Guanylate kinase-likeUniRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037640
InParanoidiQ8A677
KOiK00942
OMAiAGNYYGT
OrthoDBiPOG091H01Q4

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFSVFNFQ FSIKQMTGKL IIFSAPSGSG KSTIINYLLT QNLNLAFSIS
60 70 80 90 100
ATSRPPRGTE KHGVEYFFLT PEEFRCRIEN NEFLEYEEVY KDRYYGTLKE
110 120 130 140 150
QVEKQLEKGQ NVVFDLDVVG GCNIKKYYGE RALSIFVQPP SIEELRCRLT
160 170 180 190 200
GRGTDEPEVI ECRIAKAEYE MTFAPQFDRV IVNDDLEAAK AETLEVIKEF

LNKE
Length:204
Mass (Da):23,464
Last modified:June 1, 2003 - v1
Checksum:i2EEC38C3F761B848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO77116.1
RefSeqiNP_810922.1, NC_004663.1
WP_011108086.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO77116; AAO77116; BT_2009
GeneIDi1074911
KEGGibth:BT_2009
PATRICifig|226186.12.peg.2062

Similar proteinsi

Entry informationi

Entry nameiKGUA_BACTN
AccessioniPrimary (citable) accession number: Q8A677
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health