Reviewed,
UniProtKB/Swiss-Prot Q8A677 (KGUA_BACTN)
Last modified
February 9, 2010.
Version 47.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Guanylate kinase EC=2.7.4.8 Alternative name(s): GMP kinase | ||||
| Gene names |
| ||||
| Organism | Bacteroides thetaiotaomicron [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 818 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides |
Protein attributes
| Sequence length | 204 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328 |
| Catalytic activity | ATP + GMP = ADP + GDP. HAMAP MF_00328 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00328. |
| Sequence similarities | Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 204 | 204 | Guanylate kinase HAMAP MF_00328 | PRO_0000170499 | |||||
Regions | |||||||||
| Domain | 18 – 198 | 181 | Guanylate kinase-like | ||||||
| Nucleotide binding | 25 – 32 | 8 | ATP By similarity | ||||||
Sequences
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References
| [1] | "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE015928 Genomic DNA. Translation: AAO77116.1. |
| RefSeq | NP_810922.1. |
3D structure databases | |
| SMR | Q8A677. Positions 17-198. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1074911. |
| GenomeReviews | Gene locus BT_2009 in contig AE015928_GR. |
| KEGG | bth:BT_2009. |
| NMPDR | fig|226186.1.peg.2009. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG671982. |
| OMA | EWAEFAG. |
Enzyme and pathway databases | |
| BioCyc | BTHE226186:BT_2009-MONOMER. |
| BRENDA | 2.7.4.8. 21018. |
Family and domain databases | |
| HAMAP | MF_00328. Guanylate_kinase. [Tree] |
| InterPro | IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view] |
| Pfam | PF00625. Guanylate_kin. 1 hit. [Graphical view] |
| SMART | SM00072. GuKc. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03263. guanyl_kin. 1 hit. |
| PROSITE | PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KGUA_BACTN | ||||||||
| Accession | Primary (citable) accession number: Q8A677 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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