Q8A602 (AROC_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BT_2084

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Chorismate synthase HAMAP MF_00300		PRO_0000140554

Sequences

	Sequence		Length	Mass (Da)
	Q8A602 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: FAB6F43BEA995109	FASTA	358	39,115
	10 20 30 40 50 60 MFNSFGNIFR LTSFGESHGK GVGGVIDGFP SGITIDEEFV QQELNRRRPG QSILTTPRKE 70 80 90 100 110 120 ADKVEFLSGI FEGKSTGCPI GFIVWNENQH SNDYNNLKEV YRPSHADYTY KVKYGIRDHR 130 140 150 160 170 180 GGGRSSARET ISRVVAGALA KLALRQLGIS ITAYTSQVGA IKLEGTYSDY DLDLIETNDV 190 200 210 220 230 240 RCPDPEKAKE MADLIYKVKG EGDTIGGTLT CVIKGCPIGL GQPVFGKLHA ALGNAMLSIN 250 260 270 280 290 300 AAKAFEYGEG FKGLKMKGSE QNDVFFNNNG RIETHTNHSG GIQGGISNGQ DIYFRVVFKP 310 320 330 340 350 IATLLMEQET VNIDGVDTTL KARGRHDACV LPRAVPIVEA MAAMTILDYY LLDKTTQL

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO77191.1.
RefSeq	NP_810997.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A602.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1073422.
GenomeReviews	Gene locus BT_2084 in contig AE015928_GR.
KEGG	bth:BT_2084.
NMPDR	fig|226186.1.peg.2084.
PATRIC	21059116. VBIBacThe70966_2145.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	GVQGGIS.
PhylomeDB	Q8A602.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_2084-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BACTN

Accession

Primary (citable) accession number: Q8A602

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program