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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp), ATP-dependent 6-phosphofructokinase 2 (pfkA2), ATP-dependent 6-phosphofructokinase 3 (pfkA3), ATP-dependent 6-phosphofructokinase 1 (pfkA1)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei287Proton donorUniRule annotation1
Active sitei308UniRule annotation1
Active sitei422UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciBTHE:G13PU-7066-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:BT_2124
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805971 – 445Glucose-6-phosphate isomeraseAdd BLAST445

Proteomic databases

PaxDbiQ8A5W2
PRIDEiQ8A5W2

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BT_3172Q8A2Y33EBI-15584961,EBI-15584902

Protein-protein interaction databases

DIPiDIP-61177N
IntActiQ8A5W2, 1 interactor
STRINGi226186.BT_2124

Structurei

3D structure databases

ProteinModelPortaliQ8A5W2
SMRiQ8A5W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
InParanoidiQ8A5W2
KOiK01810
OMAiVERCKAM
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A5W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISLNIEKTF GFISKEKVSA YEAEVKAAQE MLEKGTGEGN DFLGWLHLPS
60 70 80 90 100
SISKEHLADL NATAKVLRDN CEVVIVAGIG GSYLGARAVI EALSNSFTWL
110 120 130 140 150
QDKKTAPVMI YAGHNISEDY LYELTEYLKD KKFGVINISK SGTTTETALA
160 170 180 190 200
FRLLKKQCED QRGKETAKKV IVAVTDAKKG AARVTADKEG YKTFIIPDNV
210 220 230 240 250
GGRFSVLTPV GLLPIAVAGF DIDKLVAGAA DMEKACGSDV PFAENPAAIY
260 270 280 290 300
AATRNELYRQ GKKIEILVNF CPKLHYVSEW WKQLYGESEG KDNKGIFPAS
310 320 330 340 350
VDFSTDLHSM GQWIQEGERS IFETVISLDK VDHKLEVPFD EANLDGLNFL
360 370 380 390 400
AGKRVDEVNK MAELGTQLAH VDGGVPNMRI VLPELSEYNI GGLLYFFEKA
410 420 430 440
CGISGYLLGV NPFNQPGVEA YKKNMFALLN KPGYEEESKA IQAKL
Length:445
Mass (Da):48,891
Last modified:May 23, 2003 - v1
Checksum:iC80209EA1A7E63AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO77231.1
RefSeqiNP_811037.1, NC_004663.1
WP_008759774.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO77231; AAO77231; BT_2124
GeneIDi1075192
31615449
KEGGibth:BT_2124
PATRICifig|226186.12.peg.2186

Similar proteinsi

Entry informationi

Entry nameiG6PI_BACTN
AccessioniPrimary (citable) accession number: Q8A5W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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