Q8A5U5 (DNAA_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	BT_2143

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114134
Regions
	Nucleotide binding	173 – 180	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8A5U5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 870D935B43D60C98	FASTA	470	53,251
	10 20 30 40 50 60 MIESNHVVLW NRCLEVIKDN VPETTYNTWF APIVPLKYED KTLIVQIPSQ FFYEILEEKF 70 80 90 100 110 120 VDLLRKTLYK AIGEGTKLMY NVMVDKTSIP NQTVNLEASN RSTAVTPKSI VGGNKAPSFL 130 140 150 160 170 180 KAPAVQDLDP HLNPNYNFEN FIEGYSNKLS RSVAEAVAQN PAGTAFNPLF LYGASGVGKT 190 200 210 220 230 240 HLANAIGTKI KELYADKRVL YVSAHLFQVQ YTDSVRNNTT NDFINFYQTI DVLIIDDIQE 250 260 270 280 290 300 FAGVTKTQNT FFHIFNHLHQ NGKQLILTSD RAPVLLQGME ERLLTRFKWG MVAELEKPTV 310 320 330 340 350 360 ELRKNILRNK IHRDGLQFPP EVIDYIAENV NESVRDLEGI VIAIMARSTI FNKEIDLDLA 370 380 390 400 410 420 QHIVHGVVHN ETKAVTIDDI LKVVCKHFDL EASAIHTKSR KREVVQARQI AMYLAKNYTD 430 440 450 460 470 FSTSKIGKFI GNKDHATVLH ACKTVKGQLE VDKSFQAEVQ EIESLLKKKA

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO77250.1.
RefSeq	NP_811056.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A5U5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1074333.
GenomeReviews	Gene locus BT_2143 in contig AE015928_GR.
KEGG	bth:BT_2143.
NMPDR	fig|226186.1.peg.2143.
PATRIC	21059242. VBIBacThe70966_2207.
Phylogenomic databases
HOGENOM	HBG695666.
OMA	ASVHESW.
PhylomeDB	Q8A5U5.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_2143-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_BACTN

Accession

Primary (citable) accession number: Q8A5U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program