Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8A5K8 (PSD_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:BT_2231
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000029751
Chain197 – 22832Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000029752

Sites

Site196 – 1972Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue1971Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8A5K8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: CAA44EBB5BC1AB7E

FASTA22825,810
        10         20         30         40         50         60 
MGRLKKLKKI RIHREGTHIL WASFLLLLLI NAALYWGIDC KIPFYVVAVA SIAVYLLMVN 

        70         80         90        100        110        120 
FFRCPIRLFG KDTEKIVVAP ADGKIVVIEE VDENEYFHDR RLMISIFMSI VNVHANWYPV 

       130        140        150        160        170        180 
DGTIKKVAHH NGNFMKAWLP KASTENERST VVIETPEGVE VLTRQIAGAV ARRIVTYAEV 

       190        200        210        220 
GEECYIDEHM GFIKFGSRVD VYLPLGTEVC VNMGQLTTGN QTVIAKLK

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015928 Genomic DNA. Translation: AAO77338.1.
RefSeqNP_811144.1. NC_004663.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1072545.
GenomeReviewsGene locus BT_2231 in contig AE015928_GR.
KEGGbth:BT_2231.
NMPDRfig|226186.1.peg.2231.
PATRIC21059421. VBIBacThe70966_2296.

Phylogenomic databases

HOGENOMHBG541103.
OMANERVVWH.
PhylomeDBQ8A5K8.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycBTHE226186:BT_2231-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_BACTN
AccessionPrimary (citable) accession number: Q8A5K8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents