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Protein

Thymidine kinase

Gene

tdk

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi155ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 30ATPUniRule annotation8
Nucleotide bindingi95 – 98ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:BT_2275
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749641 – 199Thymidine kinaseAdd BLAST199

Proteomic databases

PaxDbiQ8A5G4.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_2275.

Structurei

3D structure databases

ProteinModelPortaliQ8A5G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
InParanoidiQ8A5G4.
KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A5G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRMKRA KFARQRVEIF
60 70 80 90 100
KPAIDTRYSE EDVVSHDSHS IASTPIDSSA SILLFTSEID VVGIDEAQFF
110 120 130 140 150
DDGLIDVCRQ LANNGIRVII AGLDMDFKGN PFGPMPQLCA IADEVSKVHA
160 170 180 190
ICVKCGDLAS FSHRTVKNDK QVLLGETAEY EPLCRECYLR ARGEDGQKI
Length:199
Mass (Da):22,313
Last modified:June 1, 2003 - v1
Checksum:i1BADEF6335D5CDDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO77382.1.
RefSeqiNP_811188.1. NC_004663.1.
WP_008763837.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO77382; AAO77382; BT_2275.
GeneIDi1076104.
KEGGibth:BT_2275.
PATRICi21059507. VBIBacThe70966_2339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO77382.1.
RefSeqiNP_811188.1. NC_004663.1.
WP_008763837.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8A5G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_2275.

Proteomic databases

PaxDbiQ8A5G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO77382; AAO77382; BT_2275.
GeneIDi1076104.
KEGGibth:BT_2275.
PATRICi21059507. VBIBacThe70966_2339.

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
InParanoidiQ8A5G4.
KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_BACTN
AccessioniPrimary (citable) accession number: Q8A5G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.