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Q8A4M8 (GLSA_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase

EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:BT_2571
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Glutaminase HAMAP-Rule MF_00313
PRO_0000110596

Sites

Binding site691Substrate By similarity
Binding site1201Substrate By similarity
Binding site1651Substrate By similarity
Binding site1721Substrate By similarity
Binding site1961Substrate By similarity
Binding site2481Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8A4M8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 52BD1D10FF682750

FASTA32134,245
        10         20         30         40         50         60 
MDKKVTLAQL KEVVQEAYDQ VKTNTGGKNA DYIPYLANVN KDLFGISVCL LNGQTIHVGD 

        70         80         90        100        110        120 
TDYRFGIESV SKVHTAILAL RQYGAKEILD KIGADATGLP FNSIIAILLE NDHPSTPLVN 

       130        140        150        160        170        180 
AGAISACSMV QPIGDSAKKW DAIVENVTDL CGSAPQLIDE LYKSESDTNF NNRSIAWLLK 

       190        200        210        220        230        240 
NYNRIYDDPD MALDLYTRQC SLGVTALQLS VAAGTIANGG VNPVTKKEVF DASLAPKITA 

       250        260        270        280        290        300 
MIAAVGFYEH TGDWMYTSGI PAKTGVGGGV MGVLPGQFGI AAFAPPLDGA GNSVKAQLAI 

       310        320 
QYVMNKLGLN VFSDNHLIVV D 

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO77678.1.
RefSeqNP_811484.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A4M8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_2571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO77678; AAO77678; BT_2571.
GeneID1072193.
KEGGbth:BT_2571.
PATRIC21060089. VBIBacThe70966_2623.

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAWDAIVEN.
OrthoDBEOG6N94BK.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-2619-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_BACTN
AccessionPrimary (citable) accession number: Q8A4M8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families