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Protein

Glutaminase

Gene

glsA

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691SubstrateUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Binding sitei248 – 2481SubstrateUniRule annotation
Binding sitei266 – 2661Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-2619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:BT_2571
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321GlutaminasePRO_0000110596Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_2571.

Structurei

3D structure databases

ProteinModelPortaliQ8A4M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
InParanoidiQ8A4M8.
KOiK01425.
OMAiEMTMEGM.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A4M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKVTLAQL KEVVQEAYDQ VKTNTGGKNA DYIPYLANVN KDLFGISVCL
60 70 80 90 100
LNGQTIHVGD TDYRFGIESV SKVHTAILAL RQYGAKEILD KIGADATGLP
110 120 130 140 150
FNSIIAILLE NDHPSTPLVN AGAISACSMV QPIGDSAKKW DAIVENVTDL
160 170 180 190 200
CGSAPQLIDE LYKSESDTNF NNRSIAWLLK NYNRIYDDPD MALDLYTRQC
210 220 230 240 250
SLGVTALQLS VAAGTIANGG VNPVTKKEVF DASLAPKITA MIAAVGFYEH
260 270 280 290 300
TGDWMYTSGI PAKTGVGGGV MGVLPGQFGI AAFAPPLDGA GNSVKAQLAI
310 320
QYVMNKLGLN VFSDNHLIVV D
Length:321
Mass (Da):34,245
Last modified:June 1, 2003 - v1
Checksum:i52BD1D10FF682750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO77678.1.
RefSeqiNP_811484.1. NC_004663.1.
WP_008765205.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO77678; AAO77678; BT_2571.
GeneIDi1072193.
KEGGibth:BT_2571.
PATRICi21060089. VBIBacThe70966_2623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO77678.1.
RefSeqiNP_811484.1. NC_004663.1.
WP_008765205.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8A4M8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_2571.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO77678; AAO77678; BT_2571.
GeneIDi1072193.
KEGGibth:BT_2571.
PATRICi21060089. VBIBacThe70966_2623.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
InParanoidiQ8A4M8.
KOiK01425.
OMAiEMTMEGM.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-2619-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiGLSA_BACTN
AccessioniPrimary (citable) accession number: Q8A4M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 27, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.