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Protein

Glutaminase

Gene

glsA

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69SubstrateUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Binding sitei196SubstrateUniRule annotation1
Binding sitei248SubstrateUniRule annotation1
Binding sitei266Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciBTHE:G13PU-7521-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:BT_2571
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105961 – 321GlutaminaseAdd BLAST321

Proteomic databases

PaxDbiQ8A4M8
PRIDEiQ8A4M8

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_2571

Structurei

3D structure databases

ProteinModelPortaliQ8A4M8
SMRiQ8A4M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSV Bacteria
COG2066 LUCA
HOGENOMiHOG000216890
InParanoidiQ8A4M8
KOiK01425
OMAiMYTCGMY
OrthoDBiPOG091H02PU

Family and domain databases

HAMAPiMF_00313 Glutaminase, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR015868 Glutaminase
PANTHERiPTHR12544 PTHR12544, 1 hit
PfamiView protein in Pfam
PF04960 Glutaminase, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
TIGRFAMsiTIGR03814 Gln_ase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A4M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKVTLAQL KEVVQEAYDQ VKTNTGGKNA DYIPYLANVN KDLFGISVCL
60 70 80 90 100
LNGQTIHVGD TDYRFGIESV SKVHTAILAL RQYGAKEILD KIGADATGLP
110 120 130 140 150
FNSIIAILLE NDHPSTPLVN AGAISACSMV QPIGDSAKKW DAIVENVTDL
160 170 180 190 200
CGSAPQLIDE LYKSESDTNF NNRSIAWLLK NYNRIYDDPD MALDLYTRQC
210 220 230 240 250
SLGVTALQLS VAAGTIANGG VNPVTKKEVF DASLAPKITA MIAAVGFYEH
260 270 280 290 300
TGDWMYTSGI PAKTGVGGGV MGVLPGQFGI AAFAPPLDGA GNSVKAQLAI
310 320
QYVMNKLGLN VFSDNHLIVV D
Length:321
Mass (Da):34,245
Last modified:June 1, 2003 - v1
Checksum:i52BD1D10FF682750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO77678.1
RefSeqiNP_811484.1, NC_004663.1
WP_008765205.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO77678; AAO77678; BT_2571
GeneIDi1072193
31618834
KEGGibth:BT_2571
PATRICifig|226186.12.peg.2623

Similar proteinsi

Entry informationi

Entry nameiGLSA_BACTN
AccessioniPrimary (citable) accession number: Q8A4M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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