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Q8A4M8

- GLSA_BACTN

UniProt

Q8A4M8 - GLSA_BACTN

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Protein

Glutaminase

Gene
glsA, BT_2571
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691Substrate By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei172 – 1721Substrate By similarity
Binding sitei196 – 1961Substrate By similarity
Binding sitei248 – 2481Substrate By similarity
Binding sitei266 – 2661Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-2619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:BT_2571
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321GlutaminaseUniRule annotationPRO_0000110596Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_2571.

Structurei

3D structure databases

ProteinModelPortaliQ8A4M8.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiWDAIVEN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A4M8-1 [UniParc]FASTAAdd to Basket

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MDKKVTLAQL KEVVQEAYDQ VKTNTGGKNA DYIPYLANVN KDLFGISVCL    50
LNGQTIHVGD TDYRFGIESV SKVHTAILAL RQYGAKEILD KIGADATGLP 100
FNSIIAILLE NDHPSTPLVN AGAISACSMV QPIGDSAKKW DAIVENVTDL 150
CGSAPQLIDE LYKSESDTNF NNRSIAWLLK NYNRIYDDPD MALDLYTRQC 200
SLGVTALQLS VAAGTIANGG VNPVTKKEVF DASLAPKITA MIAAVGFYEH 250
TGDWMYTSGI PAKTGVGGGV MGVLPGQFGI AAFAPPLDGA GNSVKAQLAI 300
QYVMNKLGLN VFSDNHLIVV D 321
Length:321
Mass (Da):34,245
Last modified:June 1, 2003 - v1
Checksum:i52BD1D10FF682750
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO77678.1.
RefSeqiNP_811484.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO77678; AAO77678; BT_2571.
GeneIDi1072193.
KEGGibth:BT_2571.
PATRICi21060089. VBIBacThe70966_2623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO77678.1 .
RefSeqi NP_811484.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8A4M8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_2571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO77678 ; AAO77678 ; BT_2571 .
GeneIDi 1072193.
KEGGi bth:BT_2571.
PATRICi 21060089. VBIBacThe70966_2623.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi WDAIVEN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci BTHE226186:GJXV-2619-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiGLSA_BACTN
AccessioniPrimary (citable) accession number: Q8A4M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi