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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei263ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE:G13PU-7709-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:BT_2748
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195091 – 504Glutamate--tRNA ligaseAdd BLAST504

Proteomic databases

PaxDbiQ8A455
PRIDEiQ8A455

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_2748

Structurei

3D structure databases

ProteinModelPortaliQ8A455
SMRiQ8A455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 22"HIGH" regionUniRule annotationAdd BLAST11
Motifi260 – 264"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
InParanoidiQ8A455
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERKVRVRF APSPTGALHI GGVRTALYNY LFARQHGGDL IFRIEDTDSN
60 70 80 90 100
RFVPGAEEYI LESFKWLGIH FDEGVSFGGE HGPYRQSERR EIYKKYVQIL
110 120 130 140 150
LDNDKAYIAF DTPEELDAKR AEIANFQYDA STRGMMRNSL TMSKEEVDAL
160 170 180 190 200
IAEGKQYVVR FKIEPNEDVH VNDLIRGEVV INSSILDDKV LYKSADELPT
210 220 230 240 250
YHLANIVDDH LMEVSHVIRG EEWLPSAPLH VLLYRAFGWE DTMPEFAHLP
260 270 280 290 300
LLLKPEGNGK LSKRDGDRLG FPVFPLEWRP ESGEVSSGYR ESGYLPEAVI
310 320 330 340 350
NFLALLGWNP GNDQEVMSMD EMIKLFDIHR CSKSGAKFDY KKGIWFNHQY
360 370 380 390 400
IQLKPNEEIA ELFLPVLKEH GVEAPFEKVV TVVGMMKDRV SFIKELWDVC
410 420 430 440 450
SFFFVAPAEY DEKTVKKRWK EDSAKCMTEL AEVIAGIEDF SIEGQEKVVM
460 470 480 490 500
DWIAEKGYHT GNIMNAFRLT LVGEGKGPHM FDISWVLGKE ETLARMKRAV

EVLK
Length:504
Mass (Da):57,734
Last modified:June 1, 2003 - v1
Checksum:iB81EB682A53E8157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO77854.1
RefSeqiNP_811660.1, NC_004663.1
WP_008765418.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO77854; AAO77854; BT_2748
GeneIDi1072222
31614883
KEGGibth:BT_2748
PATRICifig|226186.12.peg.2795

Similar proteinsi

Entry informationi

Entry nameiSYE_BACTN
AccessioniPrimary (citable) accession number: Q8A455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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