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Q8A3I4

- Q8A3I4_BACTN

UniProt

Q8A3I4 - Q8A3I4_BACTN

Protein
Submitted name:

Alpha-L-fucosidase

Gene

BT_2970

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei83 – 831Sulfate 1; via amide nitrogenImported
    Binding sitei83 – 831Sulfate 2; via amide nitrogenImported
    Binding sitei90 – 901Sulfate 3Imported
    Binding sitei90 – 901Sulfate 4Imported
    Binding sitei97 – 971Sulfate 3; via amide nitrogenImported
    Binding sitei97 – 971Sulfate 4; via amide nitrogenImported
    Binding sitei218 – 2181Sulfate 4
    Binding sitei218 – 2181Sulfate 5Imported
    Binding sitei237 – 2371Sulfate 4
    Binding sitei237 – 2371Sulfate 7Imported
    Binding sitei262 – 2621Sulfate 6Imported
    Binding sitei271 – 2711Sulfate 4
    Binding sitei271 – 2711Sulfate 7Imported
    Binding sitei289 – 2891Sulfate 8Imported
    Binding sitei314 – 3141Sulfate 8Imported

    GO - Molecular functioni

    1. alpha-L-fucosidase activity Source: InterPro

    GO - Biological processi

    1. fucose metabolic process Source: InterPro

    Enzyme and pathway databases

    BioCyciBTHE226186:GJXV-3033-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha-L-fucosidaseImported
    Gene namesi
    Ordered Locus Names:BT_2970Imported
    OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
    Taxonomic identifieri226186 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000001414: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi226186.BT_2970.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WVSX-ray2.19A/B/C/D31-473[»]
    2WVTX-ray1.80A/B31-473[»]
    2WVUX-ray1.95A/B/C/D31-473[»]
    2WVVX-ray1.73A/B/C/D35-484[»]
    2XIBX-ray2.20A/B/C/D32-484[»]
    2XIIX-ray1.80A/B32-484[»]
    4J27X-ray1.59A/B35-484[»]
    4J28X-ray1.73A/B35-484[»]
    4JFSX-ray2.00A/B35-484[»]
    4JFTX-ray2.10A/B35-484[»]
    4JFUX-ray1.66A/B35-484[»]
    4JFVX-ray1.88A/B/C/D35-484[»]
    4JFWX-ray2.10A/B/C/D35-484[»]
    4JL1X-ray1.68A/B35-484[»]
    4JL2X-ray1.70A/B35-484[»]
    4PCSX-ray1.77A/B/C/D35-473[»]
    4PCTX-ray2.10A/B/C/D35-473[»]
    4PEEX-ray1.95A/B/C/D35-480[»]
    ProteinModelPortaliQ8A3I4.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8A3I4.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni271 – 2722Sulfate 6 bindingImported
    Regioni354 – 3563Sulfate 9 bindingImported
    Regioni375 – 3762Sulfate 10 bindingImported
    Regioni456 – 4583Sulfate 11 bindingImported
    Regioni456 – 4583Sulfate 5 binding

    Phylogenomic databases

    HOGENOMiHOG000108902.
    OMAiYNDEGID.
    OrthoDBiEOG6GXTRQ.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8A3I4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNTIIYRMK SRLITLLLLL ITVSSVTFAQ EAKKEIPLKY GATNEGKRQD    50
    PAMQKFRDNR LGAFIHWGLY AIPGGEWNGK VYGGAAEWLK SWAKVPADEW 100
    LKLMDQWNPT KFDAKKWAKM AKEMGTKYVK ITTKHHEGFC LWPSKYTKYT 150
    VANTPYKRDI LGELVKAYND EGIDVHFYFS VMDWSNPDYR YDIKSKEDSI 200
    AFSRFLEFTD NQLKELATRY PTVKDFWFDG TWDASVKKNG WWTAHAEQML 250
    KELVPGVAIN SRLRADDKGK RHFDSNGRLM GDYESGYERR LPDPVKDLKV 300
    TQWDWEACMT IPENQWGYHK DWSLSYVKTP IEVIDRIVHA VSMGGNMVVN 350
    FGPQADGDFR PEEKAMATAI GKWMNRYGKA VYACDYAGFE KQDWGYYTRG 400
    KNDEVYMVVF NQPYSERLIV KTPKGITVEK ATLLTTGEDI TVVETTRNEY 450
    NVSVPKKNPG EPYVIQLKVR AAKGTKSIYR DALT 484
    Length:484
    Mass (Da):55,914
    Last modified:June 1, 2003 - v1
    Checksum:i1A6D1745A4554F1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO78076.1.
    RefSeqiNP_811882.1. NC_004663.1.

    Genome annotation databases

    EnsemblBacteriaiAAO78076; AAO78076; BT_2970.
    GeneIDi1075834.
    KEGGibth:BT_2970.
    PATRICi21060913. VBIBacThe70966_3020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO78076.1 .
    RefSeqi NP_811882.1. NC_004663.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WVS X-ray 2.19 A/B/C/D 31-473 [» ]
    2WVT X-ray 1.80 A/B 31-473 [» ]
    2WVU X-ray 1.95 A/B/C/D 31-473 [» ]
    2WVV X-ray 1.73 A/B/C/D 35-484 [» ]
    2XIB X-ray 2.20 A/B/C/D 32-484 [» ]
    2XII X-ray 1.80 A/B 32-484 [» ]
    4J27 X-ray 1.59 A/B 35-484 [» ]
    4J28 X-ray 1.73 A/B 35-484 [» ]
    4JFS X-ray 2.00 A/B 35-484 [» ]
    4JFT X-ray 2.10 A/B 35-484 [» ]
    4JFU X-ray 1.66 A/B 35-484 [» ]
    4JFV X-ray 1.88 A/B/C/D 35-484 [» ]
    4JFW X-ray 2.10 A/B/C/D 35-484 [» ]
    4JL1 X-ray 1.68 A/B 35-484 [» ]
    4JL2 X-ray 1.70 A/B 35-484 [» ]
    4PCS X-ray 1.77 A/B/C/D 35-473 [» ]
    4PCT X-ray 2.10 A/B/C/D 35-473 [» ]
    4PEE X-ray 1.95 A/B/C/D 35-480 [» ]
    ProteinModelPortali Q8A3I4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226186.BT_2970.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO78076 ; AAO78076 ; BT_2970 .
    GeneIDi 1075834.
    KEGGi bth:BT_2970.
    PATRICi 21060913. VBIBacThe70966_3020.

    Phylogenomic databases

    HOGENOMi HOG000108902.
    OMAi YNDEGID.
    OrthoDBi EOG6GXTRQ.

    Enzyme and pathway databases

    BioCyci BTHE226186:GJXV-3033-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8A3I4.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
      Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
      Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VPI-5482Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482Imported.
    3. "Structural and thermodynamic analyses of ?-L-fucosidase inhibitors."
      Lammerts van Bueren A., Popat S.D., Lin C.H., Davies G.J.
      ChemBioChem 11:1971-1974(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 32-484.
    4. "Analysis of the reaction coordinate of alpha-L-fucosidases: a combined structural and quantum mechanical approach."
      Lammerts van Bueren A., Ardevol A., Fayers-Kerr J., Luo B., Zhang Y., Sollogoub M., Bleriot Y., Rovira C., Davies G.J.
      J. Am. Chem. Soc. 132:1804-1806(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) OF 35-484.
    5. "Three dimensional structure of a bacterial ?-l-fucosidase with a 5-membered iminocyclitol inhibitor."
      Wright D.W., Moreno-Vargas A.J., Carmona A.T., Robina I., Davies G.J.
      Bioorg. Med. Chem. 21:4751-4754(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS) OF 35-484.
    6. "?-L-fucosidase inhibition by pyrrolidine-ferrocene hybrids: rationalization of ligand-binding properties by structural studies."
      Hottin A., Wright D.W., Steenackers A., Delannoy P., Dubar F., Biot C., Davies G.J., Behr J.B.
      Chemistry 19:9526-9533(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 35-484.
    7. "Crystal structure of a bacterial fucosidase with iminocyclitol (2S,3S,4R,5S)-3,4-dihydroxy-2-ethynyl-5-methylpyrrolidine."
      Wright D.W., Davies G.J., Behr J.B.
      Submitted (APR-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 35-473.
    8. "Crystal structure of a bacterial fucosidase with iminosugar (2S,3S,4R,5S)-3,4-dihydroxy-2-[2?-phenyl]ethynyl-5-methylpyrrolidine."
      Wright D.W., Davies G.J., Behr J.B.
      Submitted (APR-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 35-473.
    9. "Crystal structure of a bacterial fucosidase with inhibitor 1-phenyl-4-[(2S,3S,4R,5S)-3,4-dihydroxy-5-methylpyrrolidin-2-yl]triazole."
      Wright D.W., Davies G.J., Behr J.B.
      Submitted (APR-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 35-480.

    Entry informationi

    Entry nameiQ8A3I4_BACTN
    AccessioniPrimary (citable) accession number: Q8A3I4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3