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Q8A3I4 (Q8A3I4_BACTN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region271 – 2722Sulfate 6 binding PDB 2XIB PDB 2WVS PDB 2WVU PDB 4JFS PDB 4JFT PDB 4J27 PDB 4J28 PDB 4JFU PDB 4JFV PDB 4JL1 PDB 4JL2
Region354 – 3563Sulfate 9 binding PDB 4JFV
Region375 – 3762Sulfate 10 binding PDB 4JL2
Region456 – 4583Sulfate 11 binding PDB 2XII
Region456 – 4583Sulfate 5 binding

Sites

Binding site831Sulfate 1; via amide nitrogen PDB 4JL1
Binding site831Sulfate 2; via amide nitrogen PDB 2XII
Binding site901Sulfate 3 PDB 4JFT PDB 4J27 PDB 4JFU PDB 4JL2
Binding site901Sulfate 4 PDB 2WVV PDB 4J28 PDB 4JL1
Binding site971Sulfate 3; via amide nitrogen PDB 4JFT PDB 4J27 PDB 4JFU PDB 4JL2
Binding site971Sulfate 4; via amide nitrogen PDB 2WVV PDB 4J28 PDB 4JL1
Binding site2181Sulfate 4
Binding site2181Sulfate 5 PDB 4J28
Binding site2371Sulfate 4
Binding site2371Sulfate 7 PDB 2XII
Binding site2621Sulfate 6 PDB 2WVU PDB 4JFT PDB 4J27 PDB 4J28 PDB 4JFU PDB 4JL1 PDB 4JL2
Binding site2711Sulfate 4
Binding site2711Sulfate 7 PDB 2XII
Binding site2891Sulfate 8 PDB 4JFW
Binding site3141Sulfate 8 PDB 4JFW

Sequences

Sequence LengthMass (Da)Tools
Q8A3I4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1A6D1745A4554F1B

FASTA48455,914
        10         20         30         40         50         60 
MKNTIIYRMK SRLITLLLLL ITVSSVTFAQ EAKKEIPLKY GATNEGKRQD PAMQKFRDNR 

        70         80         90        100        110        120 
LGAFIHWGLY AIPGGEWNGK VYGGAAEWLK SWAKVPADEW LKLMDQWNPT KFDAKKWAKM 

       130        140        150        160        170        180 
AKEMGTKYVK ITTKHHEGFC LWPSKYTKYT VANTPYKRDI LGELVKAYND EGIDVHFYFS 

       190        200        210        220        230        240 
VMDWSNPDYR YDIKSKEDSI AFSRFLEFTD NQLKELATRY PTVKDFWFDG TWDASVKKNG 

       250        260        270        280        290        300 
WWTAHAEQML KELVPGVAIN SRLRADDKGK RHFDSNGRLM GDYESGYERR LPDPVKDLKV 

       310        320        330        340        350        360 
TQWDWEACMT IPENQWGYHK DWSLSYVKTP IEVIDRIVHA VSMGGNMVVN FGPQADGDFR 

       370        380        390        400        410        420 
PEEKAMATAI GKWMNRYGKA VYACDYAGFE KQDWGYYTRG KNDEVYMVVF NQPYSERLIV 

       430        440        450        460        470        480 
KTPKGITVEK ATLLTTGEDI TVVETTRNEY NVSVPKKNPG EPYVIQLKVR AAKGTKSIYR 


DALT 

« Hide

References

« Hide 'large scale' references
[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
[2]"Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla."
Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S., Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L., Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C., Hettich R.L., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VPI-5482 EMBL AAO78076.1.
[3]"Structural and thermodynamic analyses of ?-L-fucosidase inhibitors."
Lammerts van Bueren A., Popat S.D., Lin C.H., Davies G.J.
ChemBioChem 11:1971-1974(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 32-484 IN COMPLEX WITH SULFATE.
[4]"Analysis of the reaction coordinate of alpha-L-fucosidases: a combined structural and quantum mechanical approach."
Lammerts van Bueren A., Ardevol A., Fayers-Kerr J., Luo B., Zhang Y., Sollogoub M., Bleriot Y., Rovira C., Davies G.J.
J. Am. Chem. Soc. 132:1804-1806(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) OF 35-484 IN COMPLEX WITH SULFATE.
[5]"Three dimensional structure of a bacterial ?-l-fucosidase with a 5-membered iminocyclitol inhibitor."
Wright D.W., Moreno-Vargas A.J., Carmona A.T., Robina I., Davies G.J.
Bioorg. Med. Chem. 21:4751-4754(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS) OF 35-484 IN COMPLEX WITH SULFATE.
[6]"?-L-fucosidase inhibition by pyrrolidine-ferrocene hybrids: rationalization of ligand-binding properties by structural studies."
Hottin A., Wright D.W., Steenackers A., Delannoy P., Dubar F., Biot C., Davies G.J., Behr J.B.
Chemistry 19:9526-9533(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 35-484 IN COMPLEX WITH SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO78076.1.
RefSeqNP_811882.1. NC_004663.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WVSX-ray2.19A/B/C/D31-473[»]
2WVTX-ray1.80A/B31-473[»]
2WVUX-ray1.95A/B/C/D31-473[»]
2WVVX-ray1.73A/B/C/D35-484[»]
2XIBX-ray2.20A/B/C/D32-484[»]
2XIIX-ray1.80A/B32-484[»]
4J27X-ray1.59A/B35-484[»]
4J28X-ray1.73A/B35-484[»]
4JFSX-ray2.00A/B35-484[»]
4JFTX-ray2.10A/B35-484[»]
4JFUX-ray1.66A/B35-484[»]
4JFVX-ray1.88A/B/C/D35-484[»]
4JFWX-ray2.10A/B/C/D35-484[»]
4JL1X-ray1.68A/B35-484[»]
4JL2X-ray1.70A/B35-484[»]
ProteinModelPortalQ8A3I4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_2970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO78076; AAO78076; BT_2970.
GeneID1075834.
KEGGbth:BT_2970.
PATRIC21060913. VBIBacThe70966_3020.

Phylogenomic databases

HOGENOMHOG000108902.
OMADENTWKS.
OrthoDBEOG6GXTRQ.
ProtClustDBCLSK913596.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-3033-MONOMER.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10030. PTHR10030. 1 hit.
PfamPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSPR00741. GLHYDRLASE29.
SMARTSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8A3I4.

Entry information

Entry nameQ8A3I4_BACTN
AccessionPrimary (citable) accession number: Q8A3I4
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)