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Q8A3I4

- Q8A3I4_BACTN

UniProt

Q8A3I4 - Q8A3I4_BACTN

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Protein
Submitted name: Alpha-L-fucosidase
Gene
BT_2970
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Sulfate 1; via amide nitrogenImported
Binding sitei83 – 831Sulfate 2; via amide nitrogenImported
Binding sitei90 – 901Sulfate 3Imported
Binding sitei90 – 901Sulfate 4Imported
Binding sitei97 – 971Sulfate 3; via amide nitrogenImported
Binding sitei97 – 971Sulfate 4; via amide nitrogenImported
Binding sitei218 – 2181Sulfate 4
Binding sitei218 – 2181Sulfate 5Imported
Binding sitei237 – 2371Sulfate 4
Binding sitei237 – 2371Sulfate 7Imported
Binding sitei262 – 2621Sulfate 6Imported
Binding sitei271 – 2711Sulfate 4
Binding sitei271 – 2711Sulfate 7Imported
Binding sitei289 – 2891Sulfate 8Imported
Binding sitei314 – 3141Sulfate 8Imported

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: InterPro

GO - Biological processi

  1. fucose metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-3033-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-L-fucosidaseImported
Gene namesi
Ordered Locus Names:BT_2970Imported
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_2970.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WVSX-ray2.19A/B/C/D31-473[»]
2WVTX-ray1.80A/B31-473[»]
2WVUX-ray1.95A/B/C/D31-473[»]
2WVVX-ray1.73A/B/C/D35-484[»]
2XIBX-ray2.20A/B/C/D32-484[»]
2XIIX-ray1.80A/B32-484[»]
4J27X-ray1.59A/B35-484[»]
4J28X-ray1.73A/B35-484[»]
4JFSX-ray2.00A/B35-484[»]
4JFTX-ray2.10A/B35-484[»]
4JFUX-ray1.66A/B35-484[»]
4JFVX-ray1.88A/B/C/D35-484[»]
4JFWX-ray2.10A/B/C/D35-484[»]
4JL1X-ray1.68A/B35-484[»]
4JL2X-ray1.70A/B35-484[»]
ProteinModelPortaliQ8A3I4.

Miscellaneous databases

EvolutionaryTraceiQ8A3I4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 2722Sulfate 6 bindingImported
Regioni354 – 3563Sulfate 9 bindingImported
Regioni375 – 3762Sulfate 10 bindingImported
Regioni456 – 4583Sulfate 11 bindingImported
Regioni456 – 4583Sulfate 5 binding

Phylogenomic databases

HOGENOMiHOG000108902.
OMAiYNDEGID.
OrthoDBiEOG6GXTRQ.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A3I4-1 [UniParc]FASTAAdd to Basket

« Hide

MKNTIIYRMK SRLITLLLLL ITVSSVTFAQ EAKKEIPLKY GATNEGKRQD    50
PAMQKFRDNR LGAFIHWGLY AIPGGEWNGK VYGGAAEWLK SWAKVPADEW 100
LKLMDQWNPT KFDAKKWAKM AKEMGTKYVK ITTKHHEGFC LWPSKYTKYT 150
VANTPYKRDI LGELVKAYND EGIDVHFYFS VMDWSNPDYR YDIKSKEDSI 200
AFSRFLEFTD NQLKELATRY PTVKDFWFDG TWDASVKKNG WWTAHAEQML 250
KELVPGVAIN SRLRADDKGK RHFDSNGRLM GDYESGYERR LPDPVKDLKV 300
TQWDWEACMT IPENQWGYHK DWSLSYVKTP IEVIDRIVHA VSMGGNMVVN 350
FGPQADGDFR PEEKAMATAI GKWMNRYGKA VYACDYAGFE KQDWGYYTRG 400
KNDEVYMVVF NQPYSERLIV KTPKGITVEK ATLLTTGEDI TVVETTRNEY 450
NVSVPKKNPG EPYVIQLKVR AAKGTKSIYR DALT 484
Length:484
Mass (Da):55,914
Last modified:June 1, 2003 - v1
Checksum:i1A6D1745A4554F1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO78076.1.
RefSeqiNP_811882.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO78076; AAO78076; BT_2970.
GeneIDi1075834.
KEGGibth:BT_2970.
PATRICi21060913. VBIBacThe70966_3020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO78076.1 .
RefSeqi NP_811882.1. NC_004663.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WVS X-ray 2.19 A/B/C/D 31-473 [» ]
2WVT X-ray 1.80 A/B 31-473 [» ]
2WVU X-ray 1.95 A/B/C/D 31-473 [» ]
2WVV X-ray 1.73 A/B/C/D 35-484 [» ]
2XIB X-ray 2.20 A/B/C/D 32-484 [» ]
2XII X-ray 1.80 A/B 32-484 [» ]
4J27 X-ray 1.59 A/B 35-484 [» ]
4J28 X-ray 1.73 A/B 35-484 [» ]
4JFS X-ray 2.00 A/B 35-484 [» ]
4JFT X-ray 2.10 A/B 35-484 [» ]
4JFU X-ray 1.66 A/B 35-484 [» ]
4JFV X-ray 1.88 A/B/C/D 35-484 [» ]
4JFW X-ray 2.10 A/B/C/D 35-484 [» ]
4JL1 X-ray 1.68 A/B 35-484 [» ]
4JL2 X-ray 1.70 A/B 35-484 [» ]
ProteinModelPortali Q8A3I4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_2970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO78076 ; AAO78076 ; BT_2970 .
GeneIDi 1075834.
KEGGi bth:BT_2970.
PATRICi 21060913. VBIBacThe70966_3020.

Phylogenomic databases

HOGENOMi HOG000108902.
OMAi YNDEGID.
OrthoDBi EOG6GXTRQ.

Enzyme and pathway databases

BioCyci BTHE226186:GJXV-3033-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q8A3I4.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VPI-5482Imported.
  3. "Structural and thermodynamic analyses of ?-L-fucosidase inhibitors."
    Lammerts van Bueren A., Popat S.D., Lin C.H., Davies G.J.
    ChemBioChem 11:1971-1974(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 32-484.
  4. "Analysis of the reaction coordinate of alpha-L-fucosidases: a combined structural and quantum mechanical approach."
    Lammerts van Bueren A., Ardevol A., Fayers-Kerr J., Luo B., Zhang Y., Sollogoub M., Bleriot Y., Rovira C., Davies G.J.
    J. Am. Chem. Soc. 132:1804-1806(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) OF 35-484.
  5. "Three dimensional structure of a bacterial ?-l-fucosidase with a 5-membered iminocyclitol inhibitor."
    Wright D.W., Moreno-Vargas A.J., Carmona A.T., Robina I., Davies G.J.
    Bioorg. Med. Chem. 21:4751-4754(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS) OF 35-484.
  6. "?-L-fucosidase inhibition by pyrrolidine-ferrocene hybrids: rationalization of ligand-binding properties by structural studies."
    Hottin A., Wright D.W., Steenackers A., Delannoy P., Dubar F., Biot C., Davies G.J., Behr J.B.
    Chemistry 19:9526-9533(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 35-484.

Entry informationi

Entry nameiQ8A3I4_BACTN
AccessioniPrimary (citable) accession number: Q8A3I4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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