Q8A3C0 (COAD_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopantetheine adenylyltransferase
EC=2.7.7.3

Alternative name(s):
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Short name=PPAT

Gene names

Name:	coaD
Ordered Locus Names:	BT_3034

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity. HAMAP MF_00151
Subcellular location	Cytoplasm By similarity HAMAP MF_00151.
Sequence similarities	Belongs to the bacterial CoaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	Phosphopantetheine adenylyltransferase HAMAP MF_00151		PRO_0000156170

Sequences

	Sequence		Length	Mass (Da)
	Q8A3C0 [UniParc]. Last modified June 6, 2003. Version 1. Checksum: 2D83C05D01DDEB04	FASTA	151	17,556
	10 20 30 40 50 60 MRKAIFPGTF DPFTIGHYSV VERALTFMDE IIIGIGINEN KNTYFPIEKR EEMIRNLYKD 70 80 90 100 110 120 NPRIKVMSYD CLTIDFAQQV EAQFIVRGIR TVKDFEYEET IADINRKLAG IETILLFTEP 130 140 150 ELTCVSSTIV RELLTYNKDI SQFIPEGMEI N

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO78140.1.
RefSeq	NP_811946.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A3C0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1076320.
GenomeReviews	Gene locus BT_3034 in contig AE015928_GR.
KEGG	bth:BT_3034.
NMPDR	fig|226186.1.peg.3033.
PATRIC	21061049. VBIBacThe70966_3087.
Phylogenomic databases
HOGENOM	HBG288308.
OMA	AMSDFEY.
PhylomeDB	Q8A3C0.
ProtClustDB	PRK00168.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_3034-MONOMER.
Family and domain databases
HAMAP	MF_00151. PPAT_bact. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00954.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. CoaD_prev_kdtB. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAD_BACTN

Accession

Primary (citable) accession number: Q8A3C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	June 6, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program