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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei721ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE:G13PU-8092-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BT_3126
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519741 – 944Leucine--tRNA ligaseAdd BLAST944

Proteomic databases

PaxDbiQ8A329
PRIDEiQ8A329

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_3126

Structurei

3D structure databases

ProteinModelPortaliQ8A329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi718 – 722"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
InParanoidiQ8A329
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYNFREIEK KWQQRWVEEK TYQVTEDESK QKFYVLNMFP YPSGAGLHVG
60 70 80 90 100
HPLGYIASDI YARYKRLRGF NVLNPMGYDA YGLPAEQYAI QTGQHPAITT
110 120 130 140 150
KANIDRYREQ LDKIGFSFDW SREIRTCEPE YYHWTQWAFQ KMFNSYYCND
160 170 180 190 200
EQQARPIQEL IDAFAIYGNE GLNAACSEEL SFTAKEWKAK SEKEQQEILM
210 220 230 240 250
NYRIAYLGET MVNWCQALGT VLANDEVIDG VSERGGFPVV QKKMRQWCLR
260 270 280 290 300
VSAYAQRLLD GLDTIDWTES LKETQKNWIG RSEGAEVQFK VKDSDLEFTI
310 320 330 340 350
FTTRADTMFG VTFMVLAPES DLVAQLTTPA QKAEVDAYLD RTKKRTERER
360 370 380 390 400
IADRSVTGVF SGSYAINPFT GEAVPIWISD YVLAGYGTGA IMAVPAHDSR
410 420 430 440 450
DYAFAKHFGL EIRPLVEGCD VSEESFDAKE GIVCNSPRPD VTPYCDLSLN
460 470 480 490 500
GLTIKEAIEK TKQYVKEHNL GRVKVNYRLR DAIFSRQRYW GEPFPVYYKD
510 520 530 540 550
GMPYMIDEDC LPLELPEVDK FLPTETGEPP LGHAKEWAWD TVNKCTVENE
560 570 580 590 600
KIDNVTIFPL ELNTMPGFAG SSAYYLRYMD PHNNKALVDP KVDEYWKNVD
610 620 630 640 650
LYVGGTEHAT GHLIYSRFWN KFLHDVGASV VEEPFQKLVN QGMIQGRSNF
660 670 680 690 700
VYRIKDTHTF VSLNLKDQYE VTPLHVDVNI VSNDILDLEA FKAWRPEYAE
710 720 730 740 750
AEFILEDGKY ICGWAVEKMS KSMFNVVNPD MIVDKYGADT LRMYEMFLGP
760 770 780 790 800
VEQSKPWDTN GIDGVHRFIR KFWSLFYSRT DEYLVKDEPA TKEELKSLHK
810 820 830 840 850
LIKKVTGDIE QFSYNTSVSA FMICVNELSN LKCNKKEILE QLVITLAPFA
860 870 880 890 900
PHVCEELWDT LGHETSVCDA AWPAYNEEYL KEDTINYTIS FNGKARFNME
910 920 930 940
FDADAASDAI QAAVLADERS QKWIEGKTPK KIIVVPKKIV NVVV
Length:944
Mass (Da):108,569
Last modified:June 1, 2003 - v1
Checksum:i551BEBFCD0F19DA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO78232.1
RefSeqiNP_812038.1, NC_004663.1
WP_011108648.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO78232; AAO78232; BT_3126
GeneIDi1075992
KEGGibth:BT_3126
PATRICifig|226186.12.peg.3189

Similar proteinsi

Entry informationi

Entry nameiSYL_BACTN
AccessioniPrimary (citable) accession number: Q8A329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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