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Q8A329

- SYL_BACTN

UniProt

Q8A329 - SYL_BACTN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei721 – 7211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBTHE226186:GJXV-3190-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BT_3126
    OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
    Taxonomic identifieri226186 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000001414: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 944944Leucine--tRNA ligasePRO_0000151974Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi226186.BT_3126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8A329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi718 – 7225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8A329-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNFREIEK KWQQRWVEEK TYQVTEDESK QKFYVLNMFP YPSGAGLHVG    50
    HPLGYIASDI YARYKRLRGF NVLNPMGYDA YGLPAEQYAI QTGQHPAITT 100
    KANIDRYREQ LDKIGFSFDW SREIRTCEPE YYHWTQWAFQ KMFNSYYCND 150
    EQQARPIQEL IDAFAIYGNE GLNAACSEEL SFTAKEWKAK SEKEQQEILM 200
    NYRIAYLGET MVNWCQALGT VLANDEVIDG VSERGGFPVV QKKMRQWCLR 250
    VSAYAQRLLD GLDTIDWTES LKETQKNWIG RSEGAEVQFK VKDSDLEFTI 300
    FTTRADTMFG VTFMVLAPES DLVAQLTTPA QKAEVDAYLD RTKKRTERER 350
    IADRSVTGVF SGSYAINPFT GEAVPIWISD YVLAGYGTGA IMAVPAHDSR 400
    DYAFAKHFGL EIRPLVEGCD VSEESFDAKE GIVCNSPRPD VTPYCDLSLN 450
    GLTIKEAIEK TKQYVKEHNL GRVKVNYRLR DAIFSRQRYW GEPFPVYYKD 500
    GMPYMIDEDC LPLELPEVDK FLPTETGEPP LGHAKEWAWD TVNKCTVENE 550
    KIDNVTIFPL ELNTMPGFAG SSAYYLRYMD PHNNKALVDP KVDEYWKNVD 600
    LYVGGTEHAT GHLIYSRFWN KFLHDVGASV VEEPFQKLVN QGMIQGRSNF 650
    VYRIKDTHTF VSLNLKDQYE VTPLHVDVNI VSNDILDLEA FKAWRPEYAE 700
    AEFILEDGKY ICGWAVEKMS KSMFNVVNPD MIVDKYGADT LRMYEMFLGP 750
    VEQSKPWDTN GIDGVHRFIR KFWSLFYSRT DEYLVKDEPA TKEELKSLHK 800
    LIKKVTGDIE QFSYNTSVSA FMICVNELSN LKCNKKEILE QLVITLAPFA 850
    PHVCEELWDT LGHETSVCDA AWPAYNEEYL KEDTINYTIS FNGKARFNME 900
    FDADAASDAI QAAVLADERS QKWIEGKTPK KIIVVPKKIV NVVV 944
    Length:944
    Mass (Da):108,569
    Last modified:June 1, 2003 - v1
    Checksum:i551BEBFCD0F19DA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO78232.1.
    RefSeqiNP_812038.1. NC_004663.1.
    WP_011108648.1. NC_004663.1.

    Genome annotation databases

    EnsemblBacteriaiAAO78232; AAO78232; BT_3126.
    GeneIDi1075992.
    KEGGibth:BT_3126.
    PATRICi21061253. VBIBacThe70966_3189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO78232.1 .
    RefSeqi NP_812038.1. NC_004663.1.
    WP_011108648.1. NC_004663.1.

    3D structure databases

    ProteinModelPortali Q8A329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226186.BT_3126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO78232 ; AAO78232 ; BT_3126 .
    GeneIDi 1075992.
    KEGGi bth:BT_3126.
    PATRICi 21061253. VBIBacThe70966_3189.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BTHE226186:GJXV-3190-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
      Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
      Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

    Entry informationi

    Entry nameiSYL_BACTN
    AccessioniPrimary (citable) accession number: Q8A329
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3