ID   NTPA_BACTN              Reviewed;         193 AA.
AC   Q8A327;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Nucleoside-triphosphatase;
DE            EC=3.6.1.15;
DE   AltName: Full=Nucleoside triphosphate phosphohydrolase;
DE            Short=NTPase;
GN   OrderedLocusNames=BT_3128;
OS   Bacteroides thetaiotaomicron.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
RX   MEDLINE=22550858; PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K.,
RA   Chiang H.C., Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Hydrolyzes non-standard nucleotides such as XTP and
CC       dITP/ITP. Might exclude non-standard purines from DNA precursor
CC       pool, preventing thus incorporation into DNA and avoiding
CC       chromosomal lesions (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- COFACTOR: Divalent cations (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the HAM1 NTPase family.
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DR   EMBL; AE015928; AAO78234.1; -; Genomic_DNA.
DR   RefSeq; NP_812040.1; -.
DR   HSSP; Q57679; 1B78.
DR   GeneID; 1075977; -.
DR   GenomeReviews; AE015928_GR; BT_3128.
DR   KEGG; bth:BT_3128; -.
DR   NMPDR; fig|226186.1.peg.3127; -.
DR   HOGENOM; Q8A327; -.
DR   OMA; Q8A327; VYTADWA.
DR   BioCyc; BTHE226186:BT_3128-MON; -.
DR   BRENDA; 3.6.1.15; 21018.
DR   GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:HAMAP.
DR   HAMAP; MF_01405; -; 1.
DR   InterPro; IPR002637; Ham1p-like.
DR   PANTHER; PTHR11067; Ham1p_like; 1.
DR   Pfam; PF01725; Ham1p_like; 1.
DR   TIGRFAMs; TIGR00042; Ham1p_like; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    193       Nucleoside-triphosphatase.
FT                                /FTId=PRO_0000178130.
SQ   SEQUENCE   193 AA;  21656 MW;  75D3C83E9C81185B CRC64;
     MKRKLVFATN NAHKLEEIAA ILGDKVELLS LNDIDCHTDI PETAETLEGN ALLKSSFIYR
     NYQLDCFADD TGLEVEALNG APGVYSARYA EGEGHDAQAN MRKLLHELEG KENRKAQFRT
     AISLILDGKE YLFEGVIKGE IIKEKRGDSG FGYDPIFKPE GYEQTFAELG NETKNKISHR
     ALAVQKLCEF LQR
//