Reviewed, UniProtKB/Swiss-Prot Q8A327 (NTPA_BACTN)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BT_3128

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178130

Sequences

	Sequence		Length	Mass (Da)
	Q8A327-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 75D3C83E9C81185B	FASTA	193	21,656
	10 20 30 40 50 60 MKRKLVFATN NAHKLEEIAA ILGDKVELLS LNDIDCHTDI PETAETLEGN ALLKSSFIYR 70 80 90 100 110 120 NYQLDCFADD TGLEVEALNG APGVYSARYA EGEGHDAQAN MRKLLHELEG KENRKAQFRT 130 140 150 160 170 180 AISLILDGKE YLFEGVIKGE IIKEKRGDSG FGYDPIFKPE GYEQTFAELG NETKNKISHR 190 ALAVQKLCEF LQR

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO78234.1.
RefSeq	NP_812040.1.
3D structure databases
HSSP	HSSP built from PDB template 1B78 based on UniProtKB Q57679.
ModBase	Search...
Genome annotation databases
GeneID	1075977.
GenomeReviews	Gene locus BT_3128 in contig AE015928_GR.
KEGG	bth:BT_3128.
NMPDR	fig|226186.1.peg.3127.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A327.
OMA	Q8A327. VYTADWA.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_3128-MON.
BRENDA	3.6.1.15. 21018.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BACTN

Accession

Primary (citable) accession number: Q8A327

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)