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Protein

UvrABC system protein C

Gene

uvrC

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:BT_3266
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002274021 – 609UvrABC system protein CAdd BLAST609

Proteomic databases

PaxDbiQ8A2N9.

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_3266.

Structurei

3D structure databases

ProteinModelPortaliQ8A2N9.
SMRiQ8A2N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 100GIY-YIGUniRule annotationAdd BLAST79
Domaini214 – 249UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279960.
InParanoidiQ8A2N9.
KOiK03703.
OMAiLFPIRQC.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiView protein in InterPro
IPR000305. GIY-YIG_endonuc.
IPR035901. GIY-YIG_endonuc_sf.
IPR010994. RuvA_2-like.
IPR036876. UVR_dom_sf.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
PfamiView protein in Pfam
PF01541. GIY-YIG. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiView protein in PROSITE
PS50164. GIY_YIG. 1 hit.
PS50165. UVRC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A2N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTEPEAKTN EYLRGIVANL PEKPGVYQYL NTEGTIIYVG KAKNLKKRVY
60 70 80 90 100
SYFSKEHEPG KTRVLVSKIA DIRYIVVNTE EDALLLENNL IKKYKPRYNV
110 120 130 140 150
LLKDDKTYPS ICVQNEYFPR IFRTRKIIKN GSSYYGPYSH LPSMYAVLDL
160 170 180 190 200
IKHLYPLRTC NLNLSPENIR AGKFKVCLEY HIKKCAGPCV GLQSHEDYLK
210 220 230 240 250
NIDEIKEILK GNTQDISRML VEKMQELANE MKFEEAQKIK EKYLLIENYR
260 270 280 290 300
SKSEVVSSVL HNIDVFSIEE DDSNSAFVNY LHITNGAINQ AFTFEYKKKL
310 320 330 340 350
NESKEELLTL GIIEMRERYK SHSREIIVPF ELDLELNNVV FTVPQRGDKK
360 370 380 390 400
KLLDLSILNV KQYKADRLKQ AEKLNPEQRS MRLLKEIQNE LHLDKPPLQI
410 420 430 440 450
ECFDNSNIQG SDAVAACVVF KKAKPSKKDY RKYNIKTVVG PDDYASMKEV
460 470 480 490 500
VRRRYQRAIE ENSPLPDLII TDGGKGQMEV VREVIEDELH LNIPIAGLAK
510 520 530 540 550
DNKHRTSELL FGFPAQTIGI KQQSSLFRLL TQIQDEVHRF AITFHRDKRS
560 570 580 590 600
KRQVASALDS IKGIGEKTKT ALLKEFKSVK RIKEASLEEI AKVIGEVKAQ

TVKKGLSNE
Length:609
Mass (Da):70,186
Last modified:June 1, 2003 - v1
Checksum:iD05444F98D5BB692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO78372.1.
RefSeqiNP_812178.1. NC_004663.1.
WP_011108727.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO78372; AAO78372; BT_3266.
GeneIDi1075868.
31619429.
KEGGibth:BT_3266.
PATRICifig|226186.12.peg.3331.

Similar proteinsi

Entry informationi

Entry nameiUVRC_BACTN
AccessioniPrimary (citable) accession number: Q8A2N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families