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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei178 – 1781FADUniRule annotation
Binding sitei368 – 3681FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166FADUniRule annotation
Nucleotide bindingi271 – 28515NADUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-3333-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:BT_3268
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGPRO_0000117058Add
BLAST

Proteomic databases

PaxDbiQ8A2N7.

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_3268.

Structurei

3D structure databases

ProteinModelPortaliQ8A2N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RE5. Bacteria.
COG0445. LUCA.
HOGENOMiHOG000201060.
InParanoidiQ8A2N7.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiPOG091H01O0.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8A2N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKYDVIVI GAGHAGCEAA AAAANLGSKT CLITMDMNKI GQMSCNPAVG
60 70 80 90 100
GIAKGQIVRE IDALGGQMGL VTDETAIQFR ILNRSKGPAM WSPRAQCDRA
110 120 130 140 150
KFIWSWREKL ENTPNLHIWQ DTVCELLVEN GEVVGLVTLW GVTFKAKCIV
160 170 180 190 200
LTAGTFLNGL MHVGRHQLPG GRMAEPASYQ LTESIARHGI AYGRMKTGTP
210 220 230 240 250
VRIDARSIHF DLMDTQDGEC DFHKFSFMNT STRHLKQLQC WTCYTNEEVH
260 270 280 290 300
RILREGLPDS PLFNGQIQSI GPRYCPSIET KIVTFPDKEQ HQLFLEPEGE
310 320 330 340 350
TTQELYLNGF SSSLPMDIQI AALKKVPAFK DIVIYRPGYA IEYDYFDPTQ
360 370 380 390 400
LKHSLESKII KNLFFAGQVN GTTGYEEAGG QGLIAGINAH INCHGGEAFT
410 420 430 440 450
LARDEAYIGV LIDDLVTKGV DEPYRMFTSR AEYRILLRMD DADMRLTERA
460 470 480 490 500
YHLGLAREDR YQLMKTKKEA LEQIVNFAKN YSMKPALIND ALEKLGTTPL
510 520 530 540 550
RQGCKLIEIL NRPQITIENI AEHVPAFQRE LEKATAADSD RKEEILEAAE
560 570 580 590 600
ILIKYQGYID RERMIAEKLA RLESIKIKGK FDYASIQSLS TEARQKLVKI
610 620
DPETIAQASR IPGVSPSDIN VLLVLSGR
Length:628
Mass (Da):70,257
Last modified:June 1, 2003 - v1
Checksum:i9AE06DB60E10B913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO78374.1.
RefSeqiNP_812180.1. NC_004663.1.
WP_008762875.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO78374; AAO78374; BT_3268.
GeneIDi1072307.
KEGGibth:BT_3268.
PATRICi21061543. VBIBacThe70966_3333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO78374.1.
RefSeqiNP_812180.1. NC_004663.1.
WP_008762875.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8A2N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_3268.

Proteomic databases

PaxDbiQ8A2N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO78374; AAO78374; BT_3268.
GeneIDi1072307.
KEGGibth:BT_3268.
PATRICi21061543. VBIBacThe70966_3333.

Phylogenomic databases

eggNOGiENOG4107RE5. Bacteria.
COG0445. LUCA.
HOGENOMiHOG000201060.
InParanoidiQ8A2N7.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiPOG091H01O0.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-3333-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNMG_BACTN
AccessioniPrimary (citable) accession number: Q8A2N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.