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Q8A2E9 (K6PF3_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase 3

EC=2.7.1.11
Alternative name(s):
Phosphofructokinase 3
Phosphohexokinase 3
Gene names
Name:pfkA3
Ordered Locus Names:BT_3356
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3363366-phosphofructokinase 3 HAMAP-Rule MF_00339
PRO_0000111939

Regions

Nucleotide binding20 – 245ATP By similarity
Nucleotide binding160 – 1645ATP By similarity
Nucleotide binding177 – 19317ATP By similarity

Sites

Active site1331Proton acceptor By similarity
Metal binding1911Magnesium; via carbonyl oxygen By similarity
Binding site1681Substrate By similarity
Binding site2551Substrate By similarity
Binding site2641Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8A2E9 [UniParc].

Last modified June 16, 2003. Version 1.
Checksum: 990BAEF6B5BD5F79

FASTA33635,853
        10         20         30         40         50         60 
MRIGILTSGG DCPGINATIR GVCKTAINHY GMEVIGIHSG FQGLLTKDIE SFTDKSLSGL 

        70         80         90        100        110        120 
LNQGGTMLGT SREKPFKKGG VVSDVDKPAL ILQNIQEMGL DCVVCIGGNG TQKTAAKFAA 

       130        140        150        160        170        180 
MGVNIVSVPK TIDNDIWGTD ISFGFDSAVS IATDAIDRLH STASSHKRVM VIEVMGHKAG 

       190        200        210        220        230        240 
WIALYSGMAG GGDVILVPEI PYNIKNIGNT ILERLKKGKP YSIVVVAEGI LTDGRKRAAE 

       250        260        270        280        290        300 
YIAQEIEYET GIETRETVLG YIQRGGSPTP FDRNLSTRMG GHATELIANG QFGRMIALKG 

       310        320        330 
DDISSIPLEE VAGKLKLVTE DHDLVIQGRR MGICFG 

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO78462.1.
RefSeqNP_812268.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A2E9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_3356.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO78462; AAO78462; BT_3356.
GeneID1072122.
KEGGbth:BT_3356.
PATRIC21061725. VBIBacThe70966_3424.

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248869.
KOK00850.
OMACPGINAT.
OrthoDBEOG644ZRM.
ProtClustDBPRK03202.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-3421-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
ProtoNetSearch...

Entry information

Entry nameK6PF3_BACTN
AccessionPrimary (citable) accession number: Q8A2E9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways