Q8A2E8 (RNC_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease 3
EC=3.1.26.3

Alternative name(s):
Ribonuclease III
Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	BT_3357

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity. HAMAP MF_00104
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity HAMAP MF_00104.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.
Sequence caution	The sequence AAO78463.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ribonuclease 3 HAMAP MF_00104		PRO_0000228498
Regions
	Domain	20 – 145	126	RNase III
	Domain	173 – 242	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q8A2E8 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: 8D56B9899E69296B	FASTA	311	35,973
	10 20 30 40 50 60 MLRNQIDKIR LLFRKDRESY LCFYRILGFY PHNIQIYEQA LLHKSSAVRS EKGRPLNNER 70 80 90 100 110 120 LEFLGDAILD AIVGDIVYKR FEGKREGFLT NTRSKIVQRE TLNKLAVEIG LDKLIKYSTR 130 140 150 160 170 180 SSSHNSYMYG NAFEAFIGAI YLDQGYERCK QFMEQRIINR YIDLDKISRK EVNFKSKLIE 190 200 210 220 230 240 WSQKNKMEVS FELIEQFLDH DSNPVFQTEV RIEGLPAGTG TGYSKKESQQ NAAQMAIKKV 250 260 270 280 290 300 KDQTFMDTVN EAKSQHSKPS EVETESVEPE LTESETMEPD TLETEAPEAE TTADKVETTV 310 NEVEATETEK E

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO78463.1. Different initiation.
RefSeq	NP_812269.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A2E8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1075596.
GenomeReviews	Gene locus BT_3357 in contig AE015928_GR.
KEGG	bth:BT_3357.
NMPDR	fig|226186.1.peg.3356.
PATRIC	21061727. VBIBacThe70966_3425.
Phylogenomic databases
HOGENOM	HBG744556.
OMA	DIVYKRF.
PhylomeDB	Q8A2E8.
ProtClustDB	CLSK823503.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_3357-MONOMER.
Family and domain databases
HAMAP	MF_00104. RNase_III. [Tree]
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
KO	K03685.
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_BACTN

Accession

Primary (citable) accession number: Q8A2E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program