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Protein

Ribonuclease 3

Gene

rnc

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62MagnesiumUniRule annotation1
Active sitei66UniRule annotation1
Metal bindingi131MagnesiumUniRule annotation1
Active sitei134UniRule annotation1
Metal bindingi134MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:BT_3357
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002284981 – 311Ribonuclease 3Add BLAST311

Proteomic databases

PaxDbiQ8A2E8
PRIDEiQ8A2E8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_3357

Structurei

3D structure databases

ProteinModelPortaliQ8A2E8
SMRiQ8A2E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 145RNase IIIUniRule annotationAdd BLAST126
Domaini173 – 242DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
InParanoidiQ8A2E8
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A2E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNQIDKIR LLFRKDRESY LCFYRILGFY PHNIQIYEQA LLHKSSAVRS
60 70 80 90 100
EKGRPLNNER LEFLGDAILD AIVGDIVYKR FEGKREGFLT NTRSKIVQRE
110 120 130 140 150
TLNKLAVEIG LDKLIKYSTR SSSHNSYMYG NAFEAFIGAI YLDQGYERCK
160 170 180 190 200
QFMEQRIINR YIDLDKISRK EVNFKSKLIE WSQKNKMEVS FELIEQFLDH
210 220 230 240 250
DSNPVFQTEV RIEGLPAGTG TGYSKKESQQ NAAQMAIKKV KDQTFMDTVN
260 270 280 290 300
EAKSQHSKPS EVETESVEPE LTESETMEPD TLETEAPEAE TTADKVETTV
310
NEVEATETEK E
Length:311
Mass (Da):35,973
Last modified:March 21, 2006 - v2
Checksum:i8D56B9899E69296B
GO

Sequence cautioni

The sequence AAO78463 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO78463.1 Different initiation.
RefSeqiNP_812269.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO78463; AAO78463; BT_3357
GeneIDi1075596
KEGGibth:BT_3357
PATRICifig|226186.12.peg.3425

Similar proteinsi

Entry informationi

Entry nameiRNC_BACTN
AccessioniPrimary (citable) accession number: Q8A2E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health