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Q8A2E8 (RNC_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:BT_3357
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence caution

The sequence AAO78463.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000228498

Regions

Domain20 – 145126RNase III
Domain173 – 24270DRBM

Sites

Active site661 Potential
Active site1341 By similarity
Metal binding621Magnesium By similarity
Metal binding1311Magnesium By similarity
Metal binding1341Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8A2E8 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: 8D56B9899E69296B

FASTA31135,973
        10         20         30         40         50         60 
MLRNQIDKIR LLFRKDRESY LCFYRILGFY PHNIQIYEQA LLHKSSAVRS EKGRPLNNER 

        70         80         90        100        110        120 
LEFLGDAILD AIVGDIVYKR FEGKREGFLT NTRSKIVQRE TLNKLAVEIG LDKLIKYSTR 

       130        140        150        160        170        180 
SSSHNSYMYG NAFEAFIGAI YLDQGYERCK QFMEQRIINR YIDLDKISRK EVNFKSKLIE 

       190        200        210        220        230        240 
WSQKNKMEVS FELIEQFLDH DSNPVFQTEV RIEGLPAGTG TGYSKKESQQ NAAQMAIKKV 

       250        260        270        280        290        300 
KDQTFMDTVN EAKSQHSKPS EVETESVEPE LTESETMEPD TLETEAPEAE TTADKVETTV 

       310 
NEVEATETEK E 

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO78463.1. Different initiation.
RefSeqNP_812269.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A2E8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_3357.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO78463; AAO78463; BT_3357.
GeneID1075596.
KEGGbth:BT_3357.
PATRIC21061727. VBIBacThe70966_3425.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMAQIEDSER.
OrthoDBEOG6T1WVS.
ProtClustDBCLSK823503.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-3422-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_BACTN
AccessionPrimary (citable) accession number: Q8A2E8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families