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Q8A2B1

- SPEA_BACTN

UniProt

Q8A2B1 - SPEA_BACTN

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, BT_3394
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-3459-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:BT_3394
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Biosynthetic arginine decarboxylaseUniRule annotation
PRO_0000149957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_3394.

Structurei

3D structure databases

ProteinModelPortaliQ8A2B1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 29111Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiKPLYIGF.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8A2B1-1 [UniParc]FASTAAdd to Basket

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MRKWRIEDSE ELYNITGWGT SYFSINDAGH VVVTPRRDGV TVDLKELVDE    50
LQLRDVASPM LLRFPDILDN RIEKMSSCFK QAAEEYGYKA ENFIIYPIKV 100
NQMRPVVEEI ISHGKKFNLG LEAGSKPELH AVIAVNTDSD SLIVCNGYKD 150
ESYIELALLA QKMGKRIFLV VEKMNELKLI AKMAKQLNVQ PNIGIRIKLA 200
SSGSGKWEES GGDASKFGLT SSELLEALDF MESKGLKDCL KLIHFHIGSQ 250
VTKIRRIKTA LREASQFYVQ LHSMGFNVEF VDIGGGLGVD YDGTRSSNSE 300
GSVNYSIQEY VNDSISTLVD VSDKNGIPHP NIITESGRAL TAHHSVLIFE 350
VLETATLPEW DDEEEIAPDA HELVQELYSI WDSLNQNKML EAWHDAQQIR 400
EEALDLFSHG IVDLKTRAQI ERLYWSITRE INQIAGGLKH APDEFRGLSK 450
LLADKYFCNF SLFQSLPDSW AIDQIFPIMP IQRLDEKPER SATLQDITCD 500
SDGKIANFIS TRNVAHYLPV HSLKKTEPYY LAVFLVGAYQ EILGDMHNLF 550
GDTNAVHVSV NEKGYNIEQI IDGETVAEVL DYVQYNPKKL VRTLETWVTK 600
SVKEGKISLE EGKEFLSNYR SGLYGYTYLE 630
Length:630
Mass (Da):71,246
Last modified:June 1, 2003 - v1
Checksum:iC124255A68131F19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO78500.1.
RefSeqiNP_812306.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO78500; AAO78500; BT_3394.
GeneIDi1075986.
KEGGibth:BT_3394.
PATRICi21061801. VBIBacThe70966_3462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015928 Genomic DNA. Translation: AAO78500.1 .
RefSeqi NP_812306.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8A2B1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_3394.

Protocols and materials databases

DNASUi 1075986.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO78500 ; AAO78500 ; BT_3394 .
GeneIDi 1075986.
KEGGi bth:BT_3394.
PATRICi 21061801. VBIBacThe70966_3462.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi KPLYIGF.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

BioCyci BTHE226186:GJXV-3459-MONOMER.

Family and domain databases

Gene3Di 3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiSPEA_BACTN
AccessioniPrimary (citable) accession number: Q8A2B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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