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Q8A2B1

- SPEA_BACTN

UniProt

Q8A2B1 - SPEA_BACTN

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBTHE226186:GJXV-3459-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:BT_3394
    OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
    Taxonomic identifieri226186 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000001414: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 630630Biosynthetic arginine decarboxylasePRO_0000149957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi226186.BT_3394.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8A2B1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni281 – 29111Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiKPLYIGF.
    OrthoDBiEOG676Z0R.

    Family and domain databases

    Gene3Di3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8A2B1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKWRIEDSE ELYNITGWGT SYFSINDAGH VVVTPRRDGV TVDLKELVDE    50
    LQLRDVASPM LLRFPDILDN RIEKMSSCFK QAAEEYGYKA ENFIIYPIKV 100
    NQMRPVVEEI ISHGKKFNLG LEAGSKPELH AVIAVNTDSD SLIVCNGYKD 150
    ESYIELALLA QKMGKRIFLV VEKMNELKLI AKMAKQLNVQ PNIGIRIKLA 200
    SSGSGKWEES GGDASKFGLT SSELLEALDF MESKGLKDCL KLIHFHIGSQ 250
    VTKIRRIKTA LREASQFYVQ LHSMGFNVEF VDIGGGLGVD YDGTRSSNSE 300
    GSVNYSIQEY VNDSISTLVD VSDKNGIPHP NIITESGRAL TAHHSVLIFE 350
    VLETATLPEW DDEEEIAPDA HELVQELYSI WDSLNQNKML EAWHDAQQIR 400
    EEALDLFSHG IVDLKTRAQI ERLYWSITRE INQIAGGLKH APDEFRGLSK 450
    LLADKYFCNF SLFQSLPDSW AIDQIFPIMP IQRLDEKPER SATLQDITCD 500
    SDGKIANFIS TRNVAHYLPV HSLKKTEPYY LAVFLVGAYQ EILGDMHNLF 550
    GDTNAVHVSV NEKGYNIEQI IDGETVAEVL DYVQYNPKKL VRTLETWVTK 600
    SVKEGKISLE EGKEFLSNYR SGLYGYTYLE 630
    Length:630
    Mass (Da):71,246
    Last modified:June 1, 2003 - v1
    Checksum:iC124255A68131F19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO78500.1.
    RefSeqiNP_812306.1. NC_004663.1.

    Genome annotation databases

    EnsemblBacteriaiAAO78500; AAO78500; BT_3394.
    GeneIDi1075986.
    KEGGibth:BT_3394.
    PATRICi21061801. VBIBacThe70966_3462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015928 Genomic DNA. Translation: AAO78500.1 .
    RefSeqi NP_812306.1. NC_004663.1.

    3D structure databases

    ProteinModelPortali Q8A2B1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 226186.BT_3394.

    Protocols and materials databases

    DNASUi 1075986.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO78500 ; AAO78500 ; BT_3394 .
    GeneIDi 1075986.
    KEGGi bth:BT_3394.
    PATRICi 21061801. VBIBacThe70966_3462.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi KPLYIGF.
    OrthoDBi EOG676Z0R.

    Enzyme and pathway databases

    BioCyci BTHE226186:GJXV-3459-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
      Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
      Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

    Entry informationi

    Entry nameiSPEA_BACTN
    AccessioniPrimary (citable) accession number: Q8A2B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3