Q8A2B0 (ARGB_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	BT_3395

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112588
Regions
	Region	41 – 42	2	Substrate binding By similarity
Sites
	Binding site	63	1	Substrate By similarity
	Binding site	158	1	Substrate By similarity
	Site	9	1	Transition state stabilizer By similarity
	Site	224	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8A2B0 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 52C0921F85DC6A74	FASTA	257	27,399
	10 20 30 40 50 60 MREKLTVIKV GGKIVEEEAT LLQLLNDFAA ISGHKVLVHG GGRSATKIAA QLGIESKMVN 70 80 90 100 110 120 GRRITDAETL KVVTMVYGGL VNKNIVAGLQ ARGVNALGLT GADMNVIRSV KRPVKEVDYG 130 140 150 160 170 180 FVGDVEKVDA SLLADLIHKG VVPVMAPLTH DGQGNMLNTN ADTIAGETAK ALSALFDVTL 190 200 210 220 230 240 VYCFEKKGVL RDENDDDSVI PEITRAEFEQ YVADGVIQGG MIPKLENSFE AINAGVTEVV 250 ITLASAIKDN EGTRIKK

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO78501.1.
RefSeq	NP_812307.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A2B0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1076301.
GenomeReviews	Gene locus BT_3395 in contig AE015928_GR.
KEGG	bth:BT_3395.
NMPDR	fig|226186.1.peg.3394.
PATRIC	21061803. VBIBacThe70966_3463.
Phylogenomic databases
HOGENOM	HBG497643.
OMA	GGCLVDD.
PhylomeDB	Q8A2B0.
ProtClustDB	CLSK913611.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_3395-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BACTN

Accession

Primary (citable) accession number: Q8A2B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program