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Q8A258 (MURG_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BT_3448
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000109144

Sequences

Sequence LengthMass (Da)Tools
Q8A258 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2229D02DFF85921A

FASTA37240,243
        10         20         30         40         50         60 
MEKELRIIIS GGGTGGHIFP AVSIANAIIE LRPDAKILFV GAEGRMEMQR VPDAGYKIIG 

        70         80         90        100        110        120 
LPIAGFDRKH LWKNVSVLIK LARSQWKARS IIKNFRPQVA VGVGGYASGP TLKTAGMMGV 

       130        140        150        160        170        180 
PTLIQEQNSY AGVTNKLLAQ KAKAICVAYD GMEKFFPADK IIMTGNPVRQ NLTKDMPEKG 

       190        200        210        220        230        240 
AALRSFNLQP DKKTILIVGG SLGARTINNT LTAALATIKE NNDIQFIWQT GKYYYPQVTE 

       250        260        270        280        290        300 
AVRAAGELPN LYVTDFIKDM AAAYAASDLV ISRAGAGSIS EFCLLHKPVV LVPSPNVAED 

       310        320        330        340        350        360 
HQTKNALALV DKQAAIYVKD SEAEAKLMDV ALNTVADDRK LKELSENIAK LALPDSARII 

       370 
AQEVIKLAEA EN

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References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015928 Genomic DNA. Translation: AAO78554.1.
RefSeqNP_812360.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A258.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1075127.
GenomeReviewsGene locus BT_3448 in contig AE015928_GR.
KEGGbth:BT_3448.
NMPDRfig|226186.1.peg.3447.
PATRIC21061909. VBIBacThe70966_3515.

Phylogenomic databases

HOGENOMHBG617076.
OMAEDHQTKN.
PhylomeDBQ8A258.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBTHE226186:BT_3448-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BACTN
AccessionPrimary (citable) accession number: Q8A258
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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