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Q8A255 (MRAY_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BT_3451
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108784

Regions

Transmembrane28 – 4821Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane313 – 33321Helical; Potential
Transmembrane399 – 41921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8A255 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 83EC40E61372C7BD

FASTA42246,833
        10         20         30         40         50         60 
MLYYLFEWLH KLNFPGAGMF GYTSFRALMA VILALLISSI WGDKFINLLK KKQITETQRD 

        70         80         90        100        110        120 
AKTDPFGVNK VGVPSMGGVI IIVAILIPCL LLGKLDNIYM ILMLITTVWL GSLGFADDYI 

       130        140        150        160        170        180 
KIFKKDKEGL HGKFKIIGQV GLGLIVGLTL YLSPDVVIRE NIEVHTPGQE MEVIHGTNDL 

       190        200        210        220        230        240 
KSTQTTIPFF KSNNLDYADL VGFMGEHAQT AGWFLFVIIT IFVVTAVSNG ANLNDGMDGM 

       250        260        270        280        290        300 
AAGNSAIIGA TLGILAYVSS HIEFASYLNI MYIPGSEELV IYICAFIGAL IGFLWYNAYP 

       310        320        330        340        350        360 
AQVFMGDTGS LTIGGIIAVF AIIIHKELLI PILCGVFLVE NLSVILQRFY YKIGKRKGVK 

       370        380        390        400        410        420 
QRLFKRTPIH DHFRTSMSLV EPGCTVKFTK PDQLFHESKI TVRFWIVTIV LAAITIITLK 


IR

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References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015928 Genomic DNA. Translation: AAO78557.1.
RefSeqNP_812363.1. NC_004663.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1074265.
GenomeReviewsGene locus BT_3451 in contig AE015928_GR.
KEGGbth:BT_3451.
NMPDRfig|226186.1.peg.3450.
PATRIC21061915. VBIBacThe70966_3518.

Phylogenomic databases

HOGENOMHBG708263.
OMATPASENI.
PhylomeDBQ8A255.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBTHE226186:BT_3451-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BACTN
AccessionPrimary (citable) accession number: Q8A255
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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