Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8A1D5 (PYRE_BACTN)

Last modified November 3, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10
Gene names
Name: pyrE
Ordered Locus Names: BT_3731
OrganismBacteroides thetaiotaomicron [Complete proteome] [HAMAP]
Taxonomic identifier818 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Hide | Top

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity.

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110673

Regions

Region123 – 13195-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1271Orotate By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q8A1D5-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7A6B89BBB7346872

FASTA21223,453
        10         20         30         40         50         60 
MKNLERLFAE KLLKIKAIKL QPANPFTWAS GWKSPFYCDN RKTLSYPSLR NFVKIEITRL 

        70         80         90        100        110        120 
ILERFGQVDA IAGVATGAIP QGALVADALN LPFVYVRSTP KDHGLENLIE GELRPGMKVV 

       130        140        150        160        170        180 
VVEDLISTGG SSLKAVEAIR RDGCEVIGMV AAYTYGFPVA EEAFKNAKVP LVTLTNYEAV 

       190        200        210 
LDVALRTGYI EEEDIATLND WRKDPAHWDA GK

« Hide

Hide | Top

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Hide | Top

Cross-references

Sequence databases

AE015928 Genomic DNA. Translation: AAO78836.1.
RefSeqNP_812642.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1072336.
GenomeReviewsGene locus BT_3731 in contig AE015928_GR.
KEGGbth:BT_3731.
NMPDRfig|226186.1.peg.3729.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8A1D5.
OMAHAAWVSD.

Enzyme and pathway databases

BioCycBTHE226186:BT_3731-MON.
BRENDA2.4.2.10. 21018.

Family and domain databases

HAMAPMF_01208.
[Tree]
InterProIPR004467. Or_phspho_trans.
IPR002375. Pr/py_Pribosyl_transf_CS.
IPR000836. PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. pyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry namePYRE_BACTN
AccessionPrimary (citable) accession number: Q8A1D5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents