Reviewed,
UniProtKB/Swiss-Prot Q8A1D5 (PYRE_BACTN)
Last modified
November 3, 2009.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Orotate phosphoribosyltransferase Short name=OPRT Short name=OPRTase EC=2.4.2.10 | ||||
| Gene names |
| ||||
| Organism | Bacteroides thetaiotaomicron [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 818 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides |
Protein attributes
| Sequence length | 212 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. |
| Catalytic activity | Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 |
| Cofactor | Magnesium By similarity. |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Ligand | Magnesium |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | magnesium ion binding Inferred from electronic annotation. Source: HAMAP orotate phosphoribosyltransferase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 212 | 212 | Orotate phosphoribosyltransferase HAMAP MF_01208 | PRO_0000110673 | |||||
Regions | |||||||||
| Region | 123 – 131 | 9 | 5-phosphoribose 1-diphosphate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 97 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 101 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 103 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 127 | 1 | Orotate By similarity | ||||||
Sequences
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References
| [1] | "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482. |
Cross-references
Sequence databases | |
|---|---|
| AE015928 Genomic DNA. Translation: AAO78836.1. | |
| RefSeq | NP_812642.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1072336. |
| GenomeReviews | Gene locus BT_3731 in contig AE015928_GR. |
| KEGG | bth:BT_3731. |
| NMPDR | fig|226186.1.peg.3729. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8A1D5. |
| OMA | HAAWVSD. |
Enzyme and pathway databases | |
| BioCyc | BTHE226186:BT_3731-MON. |
| BRENDA | 2.4.2.10. 21018. |
Family and domain databases | |
| HAMAP | MF_01208. [Tree] |
| InterPro | IPR004467. Or_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00336. pyrE. 1 hit. |
| PROSITE | PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRE_BACTN | ||||||||
| Accession | Primary (citable) accession number: Q8A1D5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


