Reviewed, UniProtKB/Swiss-Prot Q8A1A7 (ARGC_BACTN)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BT_3759

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112386
Sites
	Active site	132	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8A1A7-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 074D784C4F7AB7F7	FASTA	322	35,838
	10 20 30 40 50 60 MIKAGIIGGA GYTAGELIRL LLNHPETEIV FINSSSNAGN RITDVHEGLY GETDLRFTDQ 70 80 90 100 110 120 LPLDAIDVLF FCTAHGDTKK FMESHNVPED LKIIDLSMDY RIKSDDHDFI YGLPELNRRA 130 140 150 160 170 180 TCTAKHVANP GCFATCIQLG LLPLAKNLML TGDVSVNAIT GSTGAGVKPG ATSHFSWRNN 190 200 210 220 230 240 NISIYKAFDH QHVPEIKQSL KQLQNSFDSE IDFIPYRGDF PRGIFATLVV KTKVALEEIV 250 260 270 280 290 300 RMYEEYYAKD SFVHIVDKNI DLKQVVNTNK CLIHLEKHGD KLLIISCIDN LLKGASGQAV 310 320 HNMNLMFNLE ETVGLRLKPS AF

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO78864.1.
RefSeq	NP_812670.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1076380.
GenomeReviews	Gene locus BT_3759 in contig AE015928_GR.
KEGG	bth:BT_3759.
NMPDR	fig|226186.1.peg.3757.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A1A7.
OMA	Q8A1A7. TSHFSWR.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_3759-MON.
BRENDA	1.2.1.38. 21018.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACTN

Accession

Primary (citable) accession number: Q8A1A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)