Q8A146 (Q8A146_BACTN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

BT_3821

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8A146 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7223EBF8FD710673	FASTA	317	36,041
	10 20 30 40 50 60 MRVIDLIHNS EKTAFSFEIL PPLKGTGIEK LYQTVDTLRE FDPKYINITT HRSEYVYKDL 70 80 90 100 110 120 GNGLFQRNRL RRRPGTVAVA AAIQNKYNIT VVPHILCSGF TREETEYVLL DLQFLNITDL 130 140 150 160 170 180 LVLRGDKAKH ESVFTPEGDG YHHAIELQEQ INNFNKGIFV DGSEMKVTNS PFSYGVACYP 190 200 210 220 230 240 EKHEEAPNIE SDLFWLKKKV EAGAEYAVTQ LFYDNKKYFE FVEQAKAAGI NVPIIPGIKP 250 260 270 280 290 300 FKKLSQLSMV PKTFKVDLPE DLVKEALKCK NDKEAEQVGI EWCVAQCKEL MAHGVPSIHF 310 YSIGAVDSIK EVAKIIY

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO78926.1.
RefSeq	NP_812732.1. NC_004663.1.
3D structure databases
HSSP	HSSP built from PDB template 1B5T based on UniProtKB P00394.
ProteinModelPortal	Q8A146.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1072799.
GenomeReviews	Gene locus BT_3821 in contig AE015928_GR.
KEGG	bth:BT_3821.
NMPDR	fig|226186.1.peg.3819.
PATRIC	21062658. VBIBacThe70966_3885.
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	Q8A146.
ProtClustDB	CLSK913627.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8A146_BACTN

Accession

Primary (citable) accession number: Q8A146

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)