Q8A128 (CLPX_BACTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX

Gene names

Name:	clpX
Ordered Locus Names:	BT_3843

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides › Bacteroides thetaiotaomicron

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175
Subunit structure	Heterodimer of ClpP and ClpX By similarity. HAMAP-Rule MF_00175
Sequence similarities	Belongs to the ClpX chaperone family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175		PRO_0000160314
Regions
	Zinc finger	10 – 35	26	C4-type HAMAP-Rule MF_00175
	Nucleotide binding	119 – 126	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8A128 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: BD920C95AB9B7A18	FASTA	414	46,080
	10 20 30 40 50 60 MADSKTKKKC SFCGRSENEV GFLITGMNGY ICDSCATQAY EITQEALGEG RKRAGATKLN 70 80 90 100 110 120 LKELPKPVEI KKFLDQYVIG QDDAKRFLSV SVYNHYKRLL QKDSGDDVEI EKSNIIMVGS 130 140 150 160 170 180 TGTGKTLLAR TIAKLLHVPF TIVDATVLTE AGYVGEDIES ILTRLLQVAD YNVPEAEQGI 190 200 210 220 230 240 VFIDEIDKIA RKGDNPSITR DVSGEGVQQG LLKLLEGSVV NVPPQGGRKH PDQKMIPVNT 250 260 270 280 290 300 KNILFICGGA FDGIEKKIAQ RLNTHVVGYT ASQKTAVIDK NNMMQYIAPQ DLKSFGLIPE 310 320 330 340 350 360 IIGRLPVLTY LNPLDRNALR AILTEPKNSI IKQYIKLFEM DGIKLTFEDS VFEYIVDKAV 370 380 390 400 410 EYKLGARGLR SIVETIMMDV MFEIPSESKK EYKVTLDYAK QQLEKANMAR LQIA

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO78948.1.
RefSeq	NP_812754.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A128.
ModBase	Search...
Protein-protein interaction databases
STRING	226186.BT_3843.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO78948; AAO78948; BT_3843.
GeneID	1072975.
KEGG	bth:BT_3843.
PATRIC	21062712. VBIBacThe70966_3907.
Phylogenomic databases
eggNOG	COG1219.
HOGENOM	HOG000010093.
KO	K03544.
OMA	IMFEVPS.
ProtClustDB	PRK05342.
Enzyme and pathway databases
BioCyc	BTHE226186:GJXV-3917-MONOMER.
Family and domain databases
HAMAP	MF_00175. ClpX.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR019489. Clp_ATPase_C. IPR004487. Clp_protease_ATP-bd_su_ClpX. IPR027417. P-loop_NTPase. IPR010603. Znf_CppX_C4. [Graphical view]
Pfam	PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF06689. zf-C4_ClpX. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM01086. ClpB_D2-small. 1 hit. SM00994. zf-C4_ClpX. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00382. clpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CLPX_BACTN

Accession

Primary (citable) accession number: Q8A128

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program