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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 35C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi120 – 127ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBTHE:G13PU-8819-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:BT_3843
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001603141 – 414ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST414

Proteomic databases

PaxDbiQ8A128
PRIDEiQ8A128

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi226186.BT_3843

Structurei

3D structure databases

ProteinModelPortaliQ8A128
SMRiQ8A128
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 35C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN Bacteria
COG1219 LUCA
HOGENOMiHOG000010093
InParanoidiQ8A128
KOiK03544
OMAiDIMYDLP
OrthoDBiPOG091H01U4

Family and domain databases

Gene3Di3.30.50.30, 1 hit
HAMAPiMF_00175 ClpX, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004487 Clp_protease_ATP-bd_su_ClpX
IPR027417 P-loop_NTPase
IPR010603 Znf_CppX_C4
IPR038366 Znf_CppX_C4_sf
PANTHERiPTHR11262 PTHR11262, 2 hits
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
PF06689 zf-C4_ClpX, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SM00994 zf-C4_ClpX, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00382 clpX, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSKTKKKC SFCGRSENEV GFLITGMNGY ICDSCATQAY EITQEALGEG
60 70 80 90 100
RKRAGATKLN LKELPKPVEI KKFLDQYVIG QDDAKRFLSV SVYNHYKRLL
110 120 130 140 150
QKDSGDDVEI EKSNIIMVGS TGTGKTLLAR TIAKLLHVPF TIVDATVLTE
160 170 180 190 200
AGYVGEDIES ILTRLLQVAD YNVPEAEQGI VFIDEIDKIA RKGDNPSITR
210 220 230 240 250
DVSGEGVQQG LLKLLEGSVV NVPPQGGRKH PDQKMIPVNT KNILFICGGA
260 270 280 290 300
FDGIEKKIAQ RLNTHVVGYT ASQKTAVIDK NNMMQYIAPQ DLKSFGLIPE
310 320 330 340 350
IIGRLPVLTY LNPLDRNALR AILTEPKNSI IKQYIKLFEM DGIKLTFEDS
360 370 380 390 400
VFEYIVDKAV EYKLGARGLR SIVETIMMDV MFEIPSESKK EYKVTLDYAK
410
QQLEKANMAR LQIA
Length:414
Mass (Da):46,080
Last modified:June 1, 2003 - v1
Checksum:iBD920C95AB9B7A18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO78948.1
RefSeqiNP_812754.1, NC_004663.1
WP_008764111.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO78948; AAO78948; BT_3843
GeneIDi1072975
31614980
KEGGibth:BT_3843
PATRICifig|226186.12.peg.3907

Entry informationi

Entry nameiCLPX_BACTN
AccessioniPrimary (citable) accession number: Q8A128
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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