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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri10 – 3526C4-typeUniRule annotationAdd
BLAST
Nucleotide bindingi120 – 1278ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein folding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-3917-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:BT_3843
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000160314Add
BLAST

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi226186.BT_3843.

Structurei

3D structure databases

ProteinModelPortaliQ8A128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri10 – 3526C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1219.
HOGENOMiHOG000010093.
InParanoidiQ8A128.
KOiK03544.
OMAiHYKRINT.
OrthoDBiEOG625JZK.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8A128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSKTKKKC SFCGRSENEV GFLITGMNGY ICDSCATQAY EITQEALGEG
60 70 80 90 100
RKRAGATKLN LKELPKPVEI KKFLDQYVIG QDDAKRFLSV SVYNHYKRLL
110 120 130 140 150
QKDSGDDVEI EKSNIIMVGS TGTGKTLLAR TIAKLLHVPF TIVDATVLTE
160 170 180 190 200
AGYVGEDIES ILTRLLQVAD YNVPEAEQGI VFIDEIDKIA RKGDNPSITR
210 220 230 240 250
DVSGEGVQQG LLKLLEGSVV NVPPQGGRKH PDQKMIPVNT KNILFICGGA
260 270 280 290 300
FDGIEKKIAQ RLNTHVVGYT ASQKTAVIDK NNMMQYIAPQ DLKSFGLIPE
310 320 330 340 350
IIGRLPVLTY LNPLDRNALR AILTEPKNSI IKQYIKLFEM DGIKLTFEDS
360 370 380 390 400
VFEYIVDKAV EYKLGARGLR SIVETIMMDV MFEIPSESKK EYKVTLDYAK
410
QQLEKANMAR LQIA
Length:414
Mass (Da):46,080
Last modified:June 1, 2003 - v1
Checksum:iBD920C95AB9B7A18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO78948.1.
RefSeqiNP_812754.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO78948; AAO78948; BT_3843.
GeneIDi1072975.
KEGGibth:BT_3843.
PATRICi21062712. VBIBacThe70966_3907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO78948.1.
RefSeqiNP_812754.1. NC_004663.1.

3D structure databases

ProteinModelPortaliQ8A128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_3843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO78948; AAO78948; BT_3843.
GeneIDi1072975.
KEGGibth:BT_3843.
PATRICi21062712. VBIBacThe70966_3907.

Phylogenomic databases

eggNOGiCOG1219.
HOGENOMiHOG000010093.
InParanoidiQ8A128.
KOiK03544.
OMAiHYKRINT.
OrthoDBiEOG625JZK.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-3917-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiCLPX_BACTN
AccessioniPrimary (citable) accession number: Q8A128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.