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Q8A128 (CLPX_BACTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:BT_3843
OrganismBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP]
Taxonomic identifier226186 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Heterodimer of ClpP and ClpX By similarity. HAMAP-Rule MF_00175

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_0000160314

Regions

Zinc finger10 – 3526C4-type HAMAP-Rule MF_00175
Nucleotide binding119 – 1268ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q8A128 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: BD920C95AB9B7A18

FASTA41446,080
        10         20         30         40         50         60 
MADSKTKKKC SFCGRSENEV GFLITGMNGY ICDSCATQAY EITQEALGEG RKRAGATKLN 

        70         80         90        100        110        120 
LKELPKPVEI KKFLDQYVIG QDDAKRFLSV SVYNHYKRLL QKDSGDDVEI EKSNIIMVGS 

       130        140        150        160        170        180 
TGTGKTLLAR TIAKLLHVPF TIVDATVLTE AGYVGEDIES ILTRLLQVAD YNVPEAEQGI 

       190        200        210        220        230        240 
VFIDEIDKIA RKGDNPSITR DVSGEGVQQG LLKLLEGSVV NVPPQGGRKH PDQKMIPVNT 

       250        260        270        280        290        300 
KNILFICGGA FDGIEKKIAQ RLNTHVVGYT ASQKTAVIDK NNMMQYIAPQ DLKSFGLIPE 

       310        320        330        340        350        360 
IIGRLPVLTY LNPLDRNALR AILTEPKNSI IKQYIKLFEM DGIKLTFEDS VFEYIVDKAV 

       370        380        390        400        410 
EYKLGARGLR SIVETIMMDV MFEIPSESKK EYKVTLDYAK QQLEKANMAR LQIA 

« Hide

References

[1]"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015928 Genomic DNA. Translation: AAO78948.1.
RefSeqNP_812754.1. NC_004663.1.

3D structure databases

ProteinModelPortalQ8A128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING226186.BT_3843.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO78948; AAO78948; BT_3843.
GeneID1072975.
KEGGbth:BT_3843.
PATRIC21062712. VBIBacThe70966_3907.

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMAIMFEVPS.
OrthoDBEOG625JZK.
ProtClustDBPRK05342.

Enzyme and pathway databases

BioCycBTHE226186:GJXV-3917-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR013093. ATPase_AAA-2.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_BACTN
AccessionPrimary (citable) accession number: Q8A128
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families